流道结构和两相流速对微液滴制备的影响

Influence of Channel Structure and Two-phase Velocity on Droplet Manufacture

液滴微流控因其可以高效、方便地生成高单分散性液滴,被广泛应用于微材料制造、药物分析、细胞培养等领域。进一步探究流道尺寸、流量对微液滴生成和尺寸的影响,有助于对微液滴实现精准控制。通过设计不同的十字流道尺寸和控制两相流量进行微滴实验探究,研究表明了流道结构对液滴生成周期的影响,以及液滴尺寸和生成速率随流道结构出现较大差异。不同流道出口尺寸下,液滴尺寸相差约1倍,而最高生成速率可达1052.53滴/s。同时通过数值仿真解释了液滴生成周期中压力和流速的变化对液滴尺寸和生成速率的影响。

Droplet microfluidics is widely used in the fields of micromaterial manufacturing,drug analysis and cell culture,because of high efficiency and convenient generation of high monodispersity droplet.It is helpful to precisely control the microdroplet by further research of the influence of flow channel size and flow rate on the formation and size of microdroplet.Microdroplet experiments were investigated by designing the different cross channel sizes and controlling the two-phase flow.The results show that the droplet formation cycle is influenced by the structure of the channel and the droplet size and formation rate vary greatly with the different structure of the channel.The droplet size difference is about one time under different outlet sizes of the channel,and the highest formation rate is up to 1052.53 droplet/s.At the same time,the influence of pressure and velocity on droplet size and droplet formation rate during droplet formation period was explained by numerical simulation.