急性脑梗死患者血清Visfatin、adiponectin、IGF-1水平与患者脑梗死面积及神经功能缺损的相关性研究

Study on the correlation between serum Visfatin,adiponectin,IGF-1 levels and the area of cerebral infarction,the degree of neurological deficits in patients with acute cerebral infarction

【目的】探讨不同脑梗死面积、不同神经功能缺损程度的急性脑梗死患者血清内脂素(Visfatin)、脂联素(adiponectin)、胰岛素样生长因子-1(IGF-1)的表达差异。【方法】选取2019年7月至2020年12月于本院住院的急性脑梗死患者116例为观察组,根据磁共振弥散加权成像上单个病灶最大径将其分为小面积组41例、中面积组45例和大面积组30例,根据美国国立卫生研究院卒中量表(NIHSS)评分将其分为轻型组42例、中型组48例、重型组26例;同期选取本院健康体检者102例作为对照组。采用酶联免疫吸附(ELISA)法检测血清Visfatin、adiponectin、IGF-1水平;采用Pearson法分析急性脑梗死患者血清Visfatin、adiponectin、IGF-1水平间的相关性。【结果】观察组入院第1 d、第7 d、第14 d血清Visfatin水平明显高于对照组,adi鄄ponectin、IGF-1水平明显低于对照组(P<0.05)。大面积组、中面积组、小面积组入院第1 d、第7 d血清Visfatin水平依次升高,adiponectin、IGF-1水平依次降低(P均<0.05);重型组、中型组、轻型组入院第1 d、第7 d血清Visfatin水平依次升高,adi鄄ponectin、IGF-1水平依次降低(P均<0.05);同组发病入院第1 d、第7 d、第14 d,血清Visfatin水平依次降低,adiponectin、IGF-1水平依次升高(P均<0.05)。急性脑梗死患者入院第1 d血清Visfatin与adiponectin、IGF-1均呈负相关(r=-0.629、-0.603,P均<0.05),adiponectin与IGF-1呈正相关(r=0.617,P<0.05)。【结论】脑梗死面积及神经功能缺损程度较大的急性脑梗死患者早期血清Visfatin水平较高,adiponectin、IGF-1水平较低。

【Objective】To investigate the expression differences of serum visfatin,adiponectin,and insulin-like growth factor-1(IGF-1)in patients with acute cerebral infarction with different cerebral infarction areas and different degrees of neurological deficits.【Methods】A total of 116 patients with acute cerebral infarction who were hospitalized in our hospital from July 2019 to December 2020 were selected as the observation group.According to the maximum diameter of a single lesion on MRI diffusion weighted imaging,they were divided into a small area group with 41 cases,a medium area group with 45 cases,and a large area group with 30 cases.According to the National Institutes of Health Stroke Scale(NIHSS)score,they were divided into the light group with 42 cases,the medium group with 48 cases,and the severe group with 26 cases;during the same period,102 healthy patients in our hospital were selected as the control group.Enzyme-linked immunosorbent assay(ELISA)was used to detect the levels of serum Visfatin,adiponectin,and IGF-1;Pearson method was used to analyze the correlation between serum Visfatin,adiponectin and IGF-1 levels in patients with acute cerebral infarction.【Results】The level of serum Visfatin in the observation group was significantly higher than those in the control group on the 1st,7th,and 14th days of admission,and the levels of adiponectin and IGF-1 were significantly lower than those in the control group(P<0.05).The level of serum Visfatin in the large area group,medium area group,and small area group increased sequentially on the 1st and 7th day after admission,and the levels of adiponectin and IGF-1 decreased sequentially(all P<0.05);the level of serum Visfatin in the severe group,medium group,and light group increased sequentially on the 1st and 7th day after admission,and the levels of adiponectin and IGF-1 decreased sequentially(P<0.05);in the same group,the level of serum Visfatin decreased sequentially on the 1st,7th,and 14th days of admission,and the levels of adiponectin and IGF-1 increased sequentially(P<0.05).Serum Visfatin was negatively correlated with adiponectin and IGF-1 on the 1st day of admission in patients with acute cerebral infarction(r=-0.629,-0.603,P<0.05),and adiponectin was positively correlated with IGF-1(r=0.617,P<0.05).【Conclusion】Patients with acute cerebral infarction with large cerebral infarction area and neurological deficit degree have higher early serum Visfatin level,and lower adiponectin and IGF-1 levels.