SGB联合全麻在老年胃癌根治术患者中应用对认知及Aβ-42、tau-181表达的影响

Effect of SGB combined with general anesthesia on cognition and expression of Aβ-42 and tau-181 in elderly patients undergoing radical gastric cancer surgery

【目的】探讨超声引导下星状神经节阻滞(stellate ganglion block,SGB)复合全麻在胃癌根治性手术中的应用价值。【方法】选取我院拟接受胃癌根治术的老年患者86作为研究对象,采用随机数字表分为联合组与对照组,各43例,联合组在麻醉诱导前先行超声引导下SGB,两组患者的麻醉诱导药物、维持术中麻醉药物保持一致。比较两组患者的效果。【结果】术毕即刻,联合组的SjvO_(2)测定值高于对照组(P<0.05),Da-jvO_(2)、CEO_(2)测定值均低于对照组(P<0.05);联合组的Aβ-42、tau-181水平均低于对照组(P<0.05)。【结论】超声引导下SGB复合全麻在胃癌根治性手术中的应用有利于改善患者的脑氧代谢水平,减小手术引起的Aβ-42、tau-181水平,降低POCD发生率。

【Objective】To explore the value of combined general anesthesia of stellate ganglion block(SGB)under ultrasound guidance in radical operation of gastric cancer.【Methods】86 elderly patients who were to receive radical gastrectomy in our hospital were selected as the research object.The randomized digital table was divided into 43 cases in the combination group and the control group.The SGB was guided by ultrasound before anesthesia induction in the combined group.The anesthesia induced drugs and the anesthetic substance in the maintenance operation were consistent between the two groups.The effects of the two groups were compared.【Results】Immediately after the operation,the measured value of SjvO_(2)in the combined group was higher than that of the control group(P<0.05),and the measured values of Da-jvO_(2)and CEO_(2)were lower than those of the control group(P<0.05).Immediately after the operation,the levels of Aβ-42 and tau-181 in the combination group were lower than those in the control group(P<0.05).【Conclusion】The application of ultrasound-guided SGB combined with general anesthesia in radical gastric cancer surgery is beneficial to improve patients'cerebral oxygen metabolism levels,reduce the levels of Aβ-42 and tau-181 caused by surgery,and reduce the incidence of POCD.