乳腺癌来源外泌体的研究进展

Research Progress of Breast Cancer - Derived Exosomes

乳腺癌是发生在乳腺腺上皮组织的恶性肿瘤,严重影响女性健康。外泌体作为一种分泌囊泡,由于携带蛋白质、核酸等生物分子,能够介导细胞间通讯,从而参与各种生理病理过程。研究发现,乳腺癌细胞来源外泌体与近端的肿瘤微环境和远端的组织器官相互作用,这些携带肿瘤生物活性分子的外泌体参与调控乳腺癌发生发展的全过程。就近年来乳腺癌来源外泌体在参与构建肿瘤微环境、免疫应答、药物抵抗、诊断和治疗等方面的研究进展进行综述。

Breast cancer is a malignant tumor that occurs in the breast epithelial tissue,which seriously affects women's health.Exosomes,as a kind of extracellular vesicle,can mediate intercellular communication due to carrying proteins,nucleic acids and other biological molecules,and thus participate in various physiological and pathological processes.It has been found that breast cancer-derived exosomes not only interact with the proximal tumor microenvironment and distal tissues,but also participate in the occurrence and development of breast cancer.This article reviews the research progress on exosomes related with construction of tumor microenvironment,immune response,drug resistance,diagnosis and treatment of breast cancer.