重症酒精性肝炎相关感染

Severe alcoholic hepatitis associated infection

重症酒精性肝炎易合并感染,与糖皮质激素的应答及预后相关。糖皮质激素可增加严重感染和真菌感染的发生。其中细菌感染以革兰阴性菌为主,侵袭性真菌感染亦不少见。早期诊断和经验性抗感染治疗是重症酒精性肝炎合并感染的重要手段,在确定多重耐药菌感染的高风险后应及时制定覆盖多重耐药菌的抗感染策略。

Patients with severe alcoholic hepatitis is sensitive to concurrent infection and impact glucocorticoid response and disease prognosis.Glucocorticoids can increase the incidence and of serious infections and fungal infections.Among them,Gram-negative bacterial infections are the major one,and invasive fungal infections are not uncommon.Early diagnosis and empiric anti-infective therapy are important means for severe alcoholic hepatitis with concurrent infection.Anti-infective strategies covering multiple drug-resistant bacteria should be timely formulated after determining the high risk of multiple drug-resistant bacterial infections.