SAPHO综合征全脊柱病变的CT表现

The Whole-spine CT Findings in SAPHO Syndrome

目的:研究SAPHO综合征脊柱病变的CT表现特征,并进行定量分析。方法:纳入20例SAPHO综合征年轻患者,行低剂量CT检查,应用2017年强直性脊柱炎CT韧带骨赘评分(CTSS)评估椎体边缘骨赘增生、骨质破坏分布特征以及椎体骨质硬化、骨质硬化伴破坏和许莫氏结节的分布特征,评估椎间隙及椎旁软组织异常。结果:20例患者中18例提示全脊柱CT异常,145个椎体单位受累,以椎体前缘病变2.1%(68/3 312)为主,对吻状病变9.9%(82/828)与非对吻状病变7.6%(63/828)在分布上二者之间无统计学差别,1个椎间隙狭窄,椎旁软组织未见异常;诸病变颈椎、胸椎、腰椎分布无统计学差异,总体病变以胸腰段为主;CTSS与病程无相关性。结论:低剂量CT可准确反映SAPHO综合征脊柱病变的胸腰段前缘椎体骨赘形成的特征表现,CTSS无法反映病程。

Objective: To study the CT characteristics of spinal lesions in SAPHO syndrome patients,and quantitative analysis was performed. Methods: Twenty young patients with SAPHO syndrome were enrolled and underwent low-dose CT(LDCT) examination. The CT Syndesmophyte Score(CTSS) of ankylosing spondylitis in 2017 was used to evaluate the whole spine. We assessed the clinical data, the distribution characteristics and degree of lesions involved spine. Results: Eighteen patients had spinal lesions on CT. 0 ne hundred and forty-five units were involved. The lesions were detected mainly in the posterior corner 2.1%(68/3 312), There are no statistical differences in distribution between the affected vertebras with "kissing" appearance 9.9%(82/828) and "non-kissing" appearance 7.6%(63/828). One intervertebral disc space was narrowed. There is no paraspinal soft-tissue involvement. Distribution of lesions in cervical vertebrae, thoracic vertebrae and lumbar vertebrae were no statistical difference(P > 0.05). Lesions mainly occurred in thoracic vertebras and lumbar vertebras. There was no association between the CTSS and the course of the disease. Conclusion: lDCT can accurately reflect the characteristic performance of the whole spine lesions of SAPHO syndrome patients. The common sites were the posterior corner of thoracic vertebras and lumbar vertebras, and CTSS could not reflect the course of disease.