北京地区儿童血清胱抑素C参考区间的建立及影响因素分析

Establishment of reference interval of serum cystatin C in children in Beijing and analysis of its influencing factors

目的分析北京地区儿童血清胱抑素C的影响因素,建立北京地区儿童血清胱抑素C的参考区间。方法选取北京地区体检健康儿童3451例,运用颗粒增强免疫比浊法检测血清胱抑素C水平,探讨性别和年龄对胱抑素C参考区间的影响,并建立适合儿童的血清胱抑素C参考区间。结果血清胱抑素C在儿童中的参考区间因年龄和性别的差异而不断变化。年龄<1月龄参考区间为0.93~1.75 mg/L;1~3月龄参考区间为0.69~1.47 mg/L;>3~12月龄参考区间男性为0.59~1.13 mg/L,女性为0.62~1.20 mg/L;>1~18岁参考区间男性为0.55~1.03 mg/L,女性为0.52~1.02 mg/L。结论本研究建立了北京地区儿童血清胱抑素C的参考区间,胱抑素C在儿童中参考区间不同于成人,建立时应考虑年龄和性别的影响。

Objective To analyze the influencing factors of serum cystatin C in children in Beijing,and to establish the reference interval of serum cystatin C in children in Beijing.Methods Totally 3451 apparently healthy children in Beijing were selected,and the particle-enhanced immunoturbidimetric method was used to detect the serum cystatin C level,explore the influence of gender and age on the cystatin C reference interval,and establish a serum cystatin C suitable for children reference interval.Results The reference range of serum cystatin C in children varies with age and gender.The reference range of age less than 1 month was 0.93-1.75 mg/L.The reference interval of 1-3 months was 0.69-1.47 mg/L.The reference interval of>3-12 months was 0.59-1.13 mg/L for males and 0.62-1.20 mg/L for females.The reference interval of>1-18 years old was 0.55-1.03 mg/L for males and 0.52-1.02 mg/L for females.Conclusion This study established the reference interval of serum cystatin C in children in Beijing.The reference interval of cystatin C in children is different from that in adults.The influence of age and gender should be considered when establishing the reference interval.