氯硝柳胺的药理学作用及机制研究进展

Research Progress in Pharmacological Effects and Mechanisms of Niclosamide

氯硝柳胺是一种可杀灭钉螺的常用药物,也可作为肠道驱虫药,用于治疗肠道绦虫感染。氯硝柳胺口服耐受性较好,具有较强的抗增殖、促进凋亡、抗炎、抗细胞迁移、促进线粒体氧化磷酸化解偶联、诱导自噬、改变细胞物质能量代谢等药理学活性,且对体内多种信号通路有调节作用。氯硝柳胺在治疗肿瘤、细菌病毒感染、糖尿病、心血管系统疾病等方面具有潜在的应用效果,但氯硝柳胺在体内作用的确切靶点目前尚不明确,其治疗多种疾病的临床疗效仍需进一步大规模随机对照研究验证。

Niclosamide is commonly used as molluscacide and also as an anthelmintic drug which is widely used for treating intestinal tapeworm infections.Niclosamide has a good oral tolerance and strong pharmacological activities such as anti-proliferation,promoting apoptosis,anti-inflammation,anti-cell migration,promoting the uncoupling of mitochondria oxidative phosphorylation,inducing autophagy,changing cellular material and energy metabolism,and regulating a variety of in vivo signaling pathways.Niclosamide has potential application effect in the treatment of tumor,bacterial infection,diabetes and cardiovascular diseases,but the direct target of niclosamide in vivo has not been clarified,and its clinical effects in treating a variety of diseases still need to be confirmed by further large-scale randomized control studies.