microRNA-27b与结直肠癌患者血管生成拟态的相关性分析

Correlation Analysis Between MicroRNA-27b and Vasculogenic Mimicry in Colorectal Cancer Patients

目的探讨microRNA-27b与结直肠癌患者血管生成拟态的相关性。方法收集我院与合作中心2018年1月至2020年1月收治的结直肠癌患者100例作为观察组,同期收集100例健康成人作为对照组。比较两组人群血清microRNA-27b,同时分析结直肠癌患者microRNA-27b与结直肠癌患者血管生成拟态、微血管密度、淋巴管密度等病理特征的相关性。结果与对照组比较,观察组患者microRNA-27b相对表达量显著降低(0.87±0.20 vs.1.55±0.28,P=0.000)。与无血管生成拟态的结直肠癌患者相比,有血管生成拟态的结直肠癌患者microRNA-27b水平更低(0.62±0.24 vs.1.38±0.28,P=0.000)。多因素Logistics回归分析显示,血清MicroRNA-27b相对表达量<1.0、淋巴结转移、肿瘤直径≥5 cm是结直肠癌患者血管生成拟态的危险因素(P<0.05)。结论microRNA-27b在结直肠癌患者中降低,与血管生成拟态形成有关。

Objective To investigate the relationship between microRNA-27b and vasculogenic mimicry in colorectal cancer.Methods From January 2018 to January 2020,100 patients with colorectal cancer in our hospital and cooperation center were selected as observation group(OG)and 100 healthy adults as control group(CG).Serum microRNA-27b was compared,and the correlation between microRNA-27b and angiogenesis mimicry were analyzed.Results Compared with CG,relative expression of microRNA-27b in OG was significantly decreased(0.87±0.20 vs.1.55±0.28,P=0.000).Compared with colorectal cancer patients without vasculogenic mimicry,patients with vasculogenic mimicry had lower microRNA-27b(0.62±0.24 vs.1.38±0.28,P=0.000).Multivariate logistic regression analysis showed that serum microRNA-27b<1.0,lymph node metastasis and tumor diameter≥5 cm were risk factors for vasculogenic mimicry in colorectal cancer patients(P<0.05).Conclusion MicroRNA-27b could decrease in colorectal cancer patients,which would be related to vasculogenic mimicry.