基于生物合成气囊的影像造影剂的研究进展

Research progress of image contrast agent based on gas vesicles

气囊是一种遗传编码的、自然稳定的纳米结构,可以自由渗透周围介质中的气体,使其具有独特的声学、磁化率、光学特性,可作为多种成像方式的造影剂。通过对气囊基因的修饰,可制备出用于肿瘤诊断和治疗的复合材料,将气囊开发为声学报告基因具有巨大潜力。本文就基于气囊的影像造影剂的研究进展进行综述。

Gas vesicles(GVs)are genetically encoded and naturally stable nanostructures that can freely permeate to gases in the surrounding media,giving them unique acoustic,magnetic susceptibility and optical properties.GVs also can be used as contrast agents for a variety of imaging methods.By modifying GVs gene,the composite materials can be prepared for tumor diagnosis and treatment.In addition,it has great potential to develop GVs gene as acoustic reporter gene.This paper reviews the research progress of image contrast agent based on gas vesicles.