孤独症谱系障碍鼠类模型的行为学研究进展

Advances in behavioral test of rodent model with autism spectrum disorder

孤独症谱系障碍(autism spectrum disorder,ASD)是目前已知的最严重神经发育障碍性疾病之一,近年来全球发病率不断上升,病因及发病机制仍不明确。ASD许多方面的研究需要通过动物模型进行,其中鼠类模型是经典的ASD动物模型。行为学实验是评估ASD鼠类模型造模成功与否的重要工具,了解ASD鼠类模型相关行为学实验对实验研究尤为重要。该文就ASD鼠类动物模型的行为学方法进行系统性综述。

Autism spectrum disorder(ASD)is one of the most serious neurodevelopmental disorders known in the world.In recent years,the global incidence rate has been increasing,but its etiology and pathogenesis are unknown,so it is still necessary to be continuously studied.Many studies of ASD are conducted through animal models,and the rat model is a classic animal model of ASD.Behavioral test is an important tool for evaluating the success of ASD rat model.Understanding the behavioral test related to ASD rat models is particularly important for experimental research.Therefore,this article systematically reviews the behavioral methods of ASD rat models.