化疗导致右心室损伤研究进展

Research progress in right ventricular damage caused by chemotherapy

化疗药物可以引起心血管并发症,以往研究的焦点是左心室,而忽视了右心室。近年来的研究表明,化疗药物引起的心脏损害往往同时累及左右心室,因此,右心室重构不应被忽视。蒽环类药物和曲妥珠单抗等可显著影响右心室的结构与功能。化疗药物导致右心室重构的机制尚不完全清楚,可能与化疗药物对心肌的直接损伤、氧化应激、内皮功能障碍以及对肺循环的损伤有关。本文就化疗药物对右心室重构的影响进行综述。

Chemotherapeutic drugs could cause cardiovascular complications.Previous studies focused on the left ventricle,ignoring the right ventricle.Recent studies have shown that chemotherapeutic drug-induced heart injury usually synchronously involves both the right ventricle and the left ventricle,and therefore right ventricular remodeling should not be ignored.Anthracyclines,trastuzumab,etc.could significantly affect the structure and function of the right ventricle.The mechanism of right ventricular remodeling caused by chemotherapeutic drugs is not completely clear at present.It may be related to the direct myocardial injury,oxidative stress,endothelial dysfunction and pulmonary circulation damage caused by chemotherapeutic drugs.This article reviews on the effects of chemotherapeutic drugs on right ventricular remodeling.