电纺膜分层电纺工艺探究及性能评价

Study on Layered Electrospinning Process and Performance Evaluation of Electrospinning Membrane

目的:以聚乳酸-羟基乙酸共聚物(PLGA)为材料,用静电纺丝方法制备出具有分层微纳纤维分层结构的分层电纺膜支架。方法:调控转鼓接收器的转速制备有序纤维层和无序纤维层交替分层微纳结构的纤维支架。通过厚度测试、吸水率测试和拉伸试验,对电纺膜支架的特性进行测试。结果:分层纤维支架的厚度与对照组没有明显区别,定向纤维层与无序纤维层交替分层电纺的PLGA电纺膜的力学强度和亲水性提高。结论:该方法有望解决当前广泛使用的人工硬脑膜存在的微纳纤维结构单一、生物学性能不理想等问题。

Objective:Layered electrospun membrane scaffolds with layered micro nanofibers and layered structure were prepared by electrospinning poly(lactic co glycolic acid)(PLGA).Methods:by adjusting the rotation speed of the drum receiver,the ordered fiber layer and disordered fiber layer were alternately layered into micro nano structure fiber scaffolds.Result:the thickness of layered fiber scaffold had no significant difference with the control group.The mechanical strength of PLGA electrospun membrane was improved,and the water absorption and hydrophilicity of layered electrospun membrane were improved.Conclusion:It solves the problems of single micro nano fiber structure and poor biological properties of artificial dura mater.