全麻非心脏手术患者HES130/0.4电解质注射液与HES130/0.4氯化钠溶液容量治疗的效果比较

Comparation of the therapeutic effect of HES130/0.4 electrolyte injection and HES130/0.4 sodium chloride solution volume in patients undergoing general anesthesia in non-cardiac surgery

目的比较HES130/0.4氯化钠溶液与HES130/0.4电解质注射液容量治疗全麻非心脏手术患者的效果。方法选取2018年1月至2020年1月本院收治的全麻非心脏手术患者100例,依据容量治疗方法分为HES130/0.4电解质注射液组(电解质注射液组,n=50)和HES130/0.4氯化钠溶液(氯化钠溶液组,n=50),比较两组药物用量、液体用量、尿量、Hb、HCT、pH值、BE、HCO_(3)^(-)、Mg^(2+)、Na^(+)、K+、Cl^(-)水平、血钾及血氯异常率、血管活性药物使用率与不良事件发生率。结果输注前后,两组Hb、HCT、pH值、HCO_(3)^(-)、Na^(+)、Cl^(-)水平比较差异无统计学意义;输注前后,两组BE水平比较差异有统计学意义(P<0.05);输注前,两组Mg^(2+)、K+水平比较差异无统计学意义;输注后,电解质注射液组Mg^(2+)、K+水平均高于氯化钠溶液组(P<0.05)。输注后,电解质注射液组血钾异常率显著低于输注前(P<0.05),但输注前后血氯异常率比较差异无统计学意义;输注前后,氯化钠溶液组血钾异常率比较差异无统计学意义,输注后,血氯异常率显著高于输注前(P<0.05)。输注前,两组血钾异常率、血氯异常率比较差异无统计学意义,输注后,电解质注射液组血钾异常率、血氯异常率均明显低于氯化钠溶液组(P<0.05)。两组血管活性药物使用率比较差异无统计学意义。两组不良事件发生率比较差异无统计学意义。结论HES130/0.4电解质注射液容量治疗全麻非心脏手术患者的效果优于HES130/0.4氯化钠溶液。

Objective To compare the effect of HES130/0.4 electrolyte injection and HES130/0.4 sodium chloride solution volume in patients undergoing general anesthesia in non-cardiac surgery.Methods 100 patients undergoing general anesthesia and non-cardiac surgery in our hospital from January 2018 to January 2020 were selected and divided into HES130/0.4 electrolyte injection group(electrolyte injection group,n=50)and HES130/0.4 sodium chloride solution volume(sodium chloride solution group,n=50)according to the volume treatment method.The drug dosage,fluid dosage,urine output,Hb,HCT,pH value,BE,HCO_(3)^(-),Mg^(2+),Na^(+),K+,Cl^(-)levels,blood potassium and blood chloride abnormal rate,vasoactive drug use rate and adverse events incidence between two group were compared.Results Before and after the infusion,there was no significant differ-ence in the levels of Hb,HCT,pH value,HCO_(3)^(-),Na^(+),and Cl^(-)between the two groups;before and after the infusion,the difference in BE levels be-tween the two groups was statistically significant(P<0.05);before infusion,there was no significant difference in the levels of Mg^(2+)and K+between the two groups;after infusion,the levels of Mg^(2+)and K+in the electrolyte injection group were higher than those in the sodium chloride solution group(P<0.05).After the infusion,the abnormal rate of blood potassium in the electrolyte injection group was significantly lower than before the in-fusion(P<0.05),but the difference in the abnormal rate of blood chloride before and after the infusion was not statistically significant;before and af-ter the infusion,there was no significant difference in the abnormal rate of potassium in the sodium chloride solution group,and the abnormal rate of blood chlorine after the infusion was significantly higher than that before the infusion(P<0.05).Before the infusion,there was no statistically signif-icant difference in the abnormal potassium rate and abnormal chlorine rate between the two groups.After the infusion,the abnormal potassium rate and abnormal chlorine rate in the electrolyte injection group were significantly lower than those in the sodium chloride solution group(P<0.05).There was no statistically significant difference in the use of vasoactive drugs between the two groups.There was no statistically significant differ-ence in the incidence of adverse events between the two groups.Conclusion HES130/0.4 electrolyte injection is better than HES130/0.4 sodium chloride solution volume in the treatment of patients with non-cardiac surgery under general anesthesia.