阿替普酶静脉溶栓治疗急性脑梗死的临床疗效和不良反应分析

Clinical efficacy and adverse reactions of intravenous thrombolysis with alteplase in the treatment of acute cerebral infarction

目的探究阿替普酶静脉溶栓治疗急性脑梗死的临床疗效和不良反应。方法选取本院2019年1月至2020年1月收治的58例急性脑梗死患者,根据治疗方法的不同分为观察组和对照组,每组29例。对照组采用常规治疗,观察组采用阿替普酶静脉溶栓治疗。比较两组临床疗效、不良反应发生率、肢体运动功能和神经功能、自理能力恢复情况及生活质量。结果观察组治疗总有效率高于对照组,肢体运动功能和神经功能、自理能力恢复、生活质量评分均优于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论阿替普酶静脉溶栓治疗急性脑梗死疗效显著,可有效改善患者肢体运动功能和神经功能,提高自理能力及生活质量,且不良反应发生率较低,值得临床推广应用。

Objective To explore the clinical efficacy and adverse reactions of intravenous thrombolysis with alteplase in the treatment of acute cerebral infarction.Methods 58 patients with acute cerebral infarction in our hospital from January 2019 to January 2020 were selected and they were divided into observation group and control group according to different treatment methods,with 29 cases in each group.The control group was treated with routine treatment,while the observation group was treated with alteplase intravenous thrombolysis.The clinical efficacy,incidence of adverse reactions,limb motor function and nerve function,recovery of self-care ability and quality of life between the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group,limb motor function and nerve function,self-care ability recovery,quality of life scores were better than those of the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Alteplase intravenous thrombolytic therapy has sig-nificant effect on acute cerebral infarction,which can effectively improve the limb motor function and nerve function,improve self-care ability and quality of life,and has low incidence of adverse reactions,which is worthy of clinical application.