微小RNA加工剪切酶Dicer 1 rs1057035多态性与乳腺癌相关性研究

Correlation between Dicer 1 rs1057035 polymorphism and breast cancer

目的探讨微小RNA加工剪切酶Dicer 1 rs1057035多态性与中国汉族人群乳腺癌的相关性。方法收集176例女性乳腺癌患者和216例健康体检女性的外周静脉血,运用二代测序技术分析Dicer 1 rs1057035多态性在乳腺癌患者和健康体检者中的分布频率。结果Dicer 1 rs1057035基因型分布在女性乳腺癌患者和女性健康体检者中差异无统计学意义(P>0.05)。Dicer 1 rs1057035基因型分布与乳腺癌雌激素受体、孕激素受体、临床分期、肿瘤大小、淋巴结转移无关(P均>0.05)。结论Dicer 1 rs1057035可能不是中国汉族人群乳腺癌发病的易感位点。

Objective To investigate the Dicer 1 rs1057035 polymorphism and risk of breast cancer in the Chinese Han population.Methods Peripheral venous blood was collected from 176 patients with female breast cancer and 216 healthy women.The distribution frequency of Dicer 1 rs1057035 polymorphism in breast cancer and healthy subjects was analyzed by second-generation sequencing technique.Results There was no significant difference in the Dicer 1 rs1057035 genotype distribution between female breast cancer and healthy women(P>0.05).The Dicer 1 rs1057035 genotype distribution had no relationship with estrogen receptor,progesterone receptor,clinical stage,tumor size and lymph node metastasis of breast cancer(P>0.05).Conclusion Dicer 1 rs1057035 may not be a susceptibility locus for the development of breast cancer in the Chinese Han population.