力竭运动对心肌线粒体结构与功能影响的研究进展

Research Progress on the Effect of Exhaustive Exercise on the Structure and Function of Myocardial Mitochondrial

力竭运动会引起心脏心肌组织的损伤,导致心肌能量代谢障碍等不良反应的发生,而线粒体作为心肌能量代谢中最重要的细胞器,也将产生损伤。该文将对线粒体中的解偶联蛋白2(UCP2)、线粒体渗透性转换通道(MPTP)和Ca^(2+)等在心肌能量代谢中起着重要作用的物质进行探究,同时深入基因层面探讨线粒体转录因子A(mtTFA)对能量代谢的直接调控,进而可以通过对这些物质的调控,防止造成心肌能量代谢障碍。

Exhaustive exercise causes damage to the myocardial tissue and leads to adverse reactions such as disturbance of myocardial energy metabolism,and mitochondria,as the most important organelle in myocardial energy metabolism,will also be damaged.In this paper,we will explore the substances such as mitochondrial uncoupling protein 2(UCP2),mitochondrial permeability transition channel(MPTP)and Ca2+,which play an important role in myocardial energy metabolism.At the same time,we will explore the direct regulation of mitochondrial transcription factor A(mtTFA)on energy metabolism at the genetic level,so as to prevent the disturbance of myocardial energy metabolism through the regulation of these substances.