甲状腺功能与突发性聋发生及预后的相关性分析

Correlation between thyroid function and clinical characteristics and prognosis of sudden sensorineural hearing loss

目的探讨甲状腺功能与突发性聋的发生及预后的相关性。方法成人单侧突发性聋患者分为甲状腺功能正常组与异常组,两组患者给予相同的分型治疗方案,对其指标进行分析。结果293例突发性聋患者中甲状腺功能异常64例(21.84%),两组间双温试验异常率具有统计学差异(χ^(2)=22.061,P=0.000),甲状腺功能异常与年龄呈正相关。7 d后复查甲状腺功能恢复正常组与甲状腺功能仍异常组间疗效无显著性差异,甲状腺功能恢复正常组、甲状腺功能仍异常组与治疗前甲状腺功能正常组三组间疗效具有统计学差异(χ^(2)=18.023,P=0.000)。正常对照组甲状腺功能异常率5.45%,显著低于突发性聋患者(χ^(2)=8.000,P=0.005)。结论甲状腺功能血清学异常与突发性聋的发病密切相关,与年龄呈正相关,对水平半规管低频功能具有保护性作用;甲状腺功能异常的早期恢复与听力改善相关。

OBJECTIVE To investigate the correlation between thyroid function and occurrence and prognosis of sudden sensorineural hearing loss(SSHL).METHODS Adult patients with unilateral SSHL were divided into normal thyroid function group and abnormal thyroid function group.The patients in the two groups were given the same treatment.The indicators were analyzed.RESULTS Among the 293 cases of SSHL,there were 64 cases of abnormal thyroid function(21.84%).The abnormal rate of double temperature test was statistically different between the two groups(χ^(2)=22.061,P=0.000).The rate of abnormal thyroid function was positively correlated with age.After 7 days,the thyroid function serology in the abnormal thyroid function group could be returned to normal or still abnormal.There was no significant difference in the distribution of curative effect between the two subgroups.In the patients with normal thyroid function after treatment,still abnormal thyroid function and normal thyroid function before treatment,the distribution of curative effect was statistically significant(χ^(2)=18.023,P=0.000).In the normal control group,the rate of abnormal thyroid function was 5.45%,which was significantly lower than that in patients with sudden deafness(χ^(2)=8.000,P=0.005).CONCLUSION The serological abnormality of thyroid function is closely related to the pathogenesis of SSHL and has a positive correlation with age,which has a protective effect on the low frequency function of vestibular semicircular canal.The early recovery of serological abnormality of thyroid function is related to hearing improvement.