氟哌噻吨美利曲辛联合心理干预对慢性心力衰竭伴抑郁焦虑患者心功能、心理状态及生活质量的影响

Effect of Flupentixol Melitracen Combined with Psychological Intervention on Cardiac Function,Psychological State and Quality of Life in Patients with Chronic Heart Failure Complicated with Depression and Anxiety

目的:探讨氟哌噻吨美利曲辛联合心理干预对慢性心力衰竭伴抑郁焦虑患者心功能、心理状态及生活质量的影响。方法:选取2019年8月至2020年1月期间在首都医科大学附属北京安贞医院和解放军总医院第三医学中心治疗的慢性心力衰竭伴抑郁焦虑患者90例,并根据随机数字表法分为对照组(心理干预联合常规抗心衰治疗)和实验组(对照组的基础上联合氟哌噻吨美利曲辛治疗),各45例,均治疗4周。对比两组疗效、心功能、心理状态及生活质量。结果:实验组的临床总有效率高于对照组(P<0.05)。治疗4周后两组患者的广泛性焦虑量表(GAD-7)评分、健康问卷抑郁症状群量表(PHQ-9)评分降低,且实验组低于对照组(P<0.05)。治疗4周后两组患者的左室射血分数(LVEF)、心输出量(CO)、6min步行试验(6MWT)升高,且实验组高于对照组(P<0.05)。治疗4周后两组患者的社会功能、临床得分、自我认知、心理方面各维度评分升高,且实验组高于对照组(P<0.05)。结论:心理干预联合氟哌噻吨美利曲辛治疗慢性心力衰竭伴抑郁焦虑患者,可有效改善焦虑抑郁情况,提高患者生活质量,促进心功能恢复,疗效可靠。

Objective:To observe the effect of flupentixol melitracen combined with psychological intervention on cardiac function,psychological state and quality of life in patients with chronic heart failure complicated with depression and anxiety.Methods:90 patients with chronic heart failure complicated with depression and anxiety in Beijing Anzhen Hospital Affiliated to Capital Medical University and the third medical center of PLA General Hospital from August 2019 to January 2020 were selected,they were divided into control group(psychological intervention combined with conventional anti heart failure treatment)and experimental group(combined with Flupentixol melitracen on the basis of control group treatment)according to the random number table method,45 cases in each group,all patients were treated for 4 weeks.The curative effect,cardiac function,psychological state and quality of life of the two groups were compared.Results:The total clinical effective rate of the experimental group was higher than that of the control group(P<0.05).The scores of generalized anxiety scale(GAD-7)and health questionnaire depression symptom group scale(PHQ-9)of the two groups decreased at 4 weeks after treatment,and the experimental group was lower than the control group(P<0.05).The left ventricular ejection fraction(LVEF),cardiac output(CO)and 6-minute walk test(6 MWT)of the two groups increased at 4 weeks after treatment,and the experimental group was higher than the control group(P<0.05).The scores of social function,clinical score,self cognition and psychological aspects of the two groups increased at 4 weeks after treatment,and the experimental group was higher than the control group(P<0.05).Conclusion:Psychological intervention combined with Flupentixol melitracen in the treatment of chronic heart failure patients complicated with depression and anxiety can effectively improve the anxiety and depression state,improve the quality of life of patients,and promote the recovery of cardiac function,with reliable efficacy.