摘要
目的:根据青海地区妇女宫颈人乳头瘤病毒(HPV)检测结果,分析宫颈高危HPV(HR-HPV)感染分布特点,为指导HPV疫苗接种提供理论依据。方法:采用Hybriuax技术检测21种高危型HPV亚型,对2014年1月-2020年2月于我院就诊的46273例女性宫颈人乳头瘤病毒分型检测。结果:46273例妇女中,高危HPV阳性率10.23%,高危HPV阳性率和年龄之间存在线性趋势,随年龄的增大感染比例上升。单一高危亚型HPV感染前三位的HPV亚型为16、58和39,合计占到45.64%。HPV亚型感染以单高危阳性为主,占总HPV阳性数的88.26%,占全部筛查人数的9.03%。HPV16、58、31、68亚型阳性率和年龄段之间存在线性趋势,随年龄的增大感染比例上升。HPV感染亚型检出构成比各年龄段均以HPV16感染排在第一位,排在第二位除61-70岁为双高危外,均为HPV58为主。结论:青海地区女性HPV感染率较高,以单一高危型感染为主,HPV16、58、39、52是主要的感染亚型,所以应针对青海地区HPV感染状况设计具有针对性的预防HPV感染亚型的疫苗。
Objective:According to the cervical human papillomavirus(HPV)detection results of women in Qinghai area,to analyze the distribution characteristics of cervical high-risk HPV(HR-HPV)infection and provide theoretical basis for the guidance of using HPV vaccination.Methods:The Hybriuax technology was used to detect 21 kinds of high-risk HPV subtypes,and the subtypes of HPV in46,273 women visited our hospital from January 2014 to February 2020 was tested.Results:The positive rate of high risk HPV was10.23%among 46,273 women.There was a linear trend between the patients’detection positive rate of high-risk HPV and age,and the infection rate increased with the increase of age.The top three HPV subtypes of single high-risk HPV infection were subtypes 16,58 and39,accounting for 45.64%in total.The majority HPV subtypes infection were single high-risk HPV detection positive,accounting for88.26%of the total number of HPV positive,and 9.03%of the total number of people screened.The positive rates of HPV subtypes 16,58,31 and 68 showed a linear trend with age,and the infection rate increased with age.HPV-16 infection ranked first in all age groups,HPV-58 infection ranked second in all age groups except for those aged 61-70 who were with double high-risk HPV infection.Conclusion:Women in Qinghai area have a high rate of HPV infection,which is mainly caused by single high-risk infection,and subtypes 16,58,39 and 52 of high-risk HPV are the main infection subtypes.Therefore,according to the status of HPV infection in Qinghai,targeted vaccines should be designed to prevent HPV infection.
作者
靳冬梅
伍东月
莹杰
杜瑞亭
郭清民
JIN Dong-mei;WU Dong-yue;YING Jie;DU Rui-ting;GUO Qing-min(Department of Gynaecology,Qinghai Provincial People's Hospital,Xining,Qinghai,810007,China)
出处
《现代生物医学进展》
CAS
2021年第15期2982-2985,共4页
Progress in Modern Biomedicine
基金
青海省卫健委2020年基础研究指导项目(2020-wjzdx-06)。
关键词
青海
宫颈
人乳头瘤病毒
高危亚型
Qinghai
Cervical
Human papilloma virus
High-risk subtype