MTHFR、MTRR基因多态性与中国女性多囊卵巢综合征相关性的meta分析

Association of MTHFR、MTRR gene polymorphisms of Chinese women with the risk of polycystic ovary syndrome:A meta analysis

目的:系统评价基因MTHFR C677T和A1298C、MTRR A66G多态性与中国女性多囊卵巢综合征(PCOS)的相关性。方法:计算机检索PubMed、Web of Science、EMBASE、CNKI、WanFang和VIP等中英文数据库,搜集关于MTHFR C677T和A1298C、MTRR A66G基因多态性与中国女性PCOS相关的病例对照研究。采用Stata 11.0软件进行meta分析,计算优势比及95%置信区间评价其关联度,同时进行敏感性分析及发表偏移的评估。结果:共纳入8项MTHFR C677T基因多态与PCOS相关性的病例对照研究(PCOS 1424例,健康对照1576例),7项MTHFR A1298C基因多态性与PCOS相关性的病例对照研究(PCOS 1079例,健康对照1269例)和4项MTRR A66G基因多态与PCOS相关性的病例对照研究(PCOS 522例,健康对照633例)。MTHFR C677T的5种模型T比C(OR=1.48,95%CI 1.06~2.08)、TT比CC(OR=2.08,95%CI 1.08~4.02)、CT比CC(OR=1.64,95%CI 1.09~2.49)、(TT+CT)比CC(OR=1.78,95%CI 1.09~2.89)、TT比(CC+CT)(OR=1.60,95%CI 1.06~2.42);MTHFR A1298C的5种模型C比A(OR=1.54,95%CI 1.30~1.82)、CC比AA(OR=1.54,95%CI 1.35~1.76)、AC比AA(OR=1.19,95%CI 1.08~1.31)和(CC+AC)比AA(OR=1.25,95%CI 1.15~1.37),MTRR A66G的隐性比较模型GG比(AG+AA)(OR=1.58,95%CI 1.37~1.83)与PCOS相关。结论:MTHFR C677T和A1298C、MTRR A66G基因多态性与中国女性PCOS有关。

Objective:To assess the relationship between the gene polymorphisms of MTHFR C677T and MTRR A66G of Chinese women and their risk of polycystic ovary syndrome(PCOS).Methods:Databases including PubMed,Web of Science,EMBASE,CNKI,Wanfang,and VIP were searched by computer,and the case-control studies about the relationship between the gene polymorphisms of MTHFR C677T,A1298C,and MTRR A66G of Chinese women and their risk of PCOS were retrieved and collect.State software 11.0 was used to do the meta analysis,the relevancy of the gene polymorphisms of MTHFR C677T,A1298C,and MTRR A66G of the women and their of PCOS was evaluated by odds ratio and its 95%confidence interval(95%CI),and the sensitivity analysis and publication bias were also conducted.Results:8 case-control studies about the relationship between the gene polymorphisms of MTHFR C677T of Chinese women and their risk of PCOS were included,which included 1424 women with PCOS and 1576 healthy women.7 case-control studies about the relationship between the gene polymorphisms of MTHFR A1298C of Chinese women and their risk of PCOS were included,which included 1079 women with PCOS and 1269 healthy women.4 case-control studies about the relationship between the gene polymorphisms of MTRR A66G of Chinese women and their risk of PCOS were included,and which included 522 women with PCOS and 633 healthy women.There were 5 models of MTHFR C677T,which included T vs.C(OR=1.48,95%:1.06-2.08),TT vs.CC(OR=2.08,95%:1.08-4.02),CT vs.CC(OR=1.64,95%:1.09-2.49),(TT+CT)vs.CC(OR=1.78,95%:1.09-2.89),and TT vs.(CC+CT)(OR=1.60,95%:1.06-2.42).There were 5 models of MTHFR A1298C,which included:C vs.A(OR=1.54,95%:1.30-1.82),CC vs.AA(OR=1.54,95%:1.35-1.76),AC vs.AA(OR=1.19,95%:1.08-1.31),and(CC+AC)vs.AA(OR=1.25,95%:1.15-1.37).The GG vs.(AG+AA)and GG vs.(AG+AA)as recessive comparison model of MTRR A66G were related to the risk of PCOS(OR=1.58,95%:1.37-1.83).Conclusion:There are the associations of the gene polymorphisms of MTHFR C677T,A1298C,and MTRR A66G of Chinese women with their risk of PCOS.