早孕药物流产后异常子宫出血者Ang-1、CD1a和CD56表达分析

Relationship between the expression levels of angiogenin-1,CD1a,and CD56 of the women with medical abortion by mifepristone and their abnormal uterine bleeding

目的:分析早孕药物流产后异常子宫出血者血浆中血管生成素-1(Ang-1)及胎囊组织中CD1a和CD56表达变化。方法:2016年9月-2018年12月本院收治的药物流产终止妊娠85例,分为异常出血组(子宫出血>14d)和对照组(子宫出血<14d);放射免疫法检测两组血浆Ang-1水平,免疫组织化学法检测胎囊组织中CD1a和CD56水平;logistics回归模型分析Ang-1、CD1a和CD56表达与终止妊娠后异常子宫出血关系。结果:异常出血组Ang-1(365.38±32.15 ng/L)、CD1a(25.38±5.21)%和CD56(15.81±3.39)%表达均高于对照组(258.67±28.91 ng/L、8.65%±2.13%、5.68%±1.58%)(P<0.05);高Ang-1、高CD1a和高CD56表达水平是米非司酮终止妊娠后异常子宫出血的独立危险因素(P<0.05)。结论:米非司酮终止妊娠后异常子宫出血者体内Ang-1、CD1a和CD56呈异常高表达状态,且3项高表达均是异常子宫出血的独立危险因素。

Objective:To analyze the change of the expression levels of plasma angiogenin-1(Ang-1),and the CD1a,and CD56 in fetal sac tissue of the women with abnormal uterine bleeding after medical abortion by mifepristone.Methods:85 women after medical abortion by mifepristone were included and were divided into group A(women with abnormal uterine bleeding>14d)and group B(women with uterine bleeding<14d).Radioimmunoassay was used to detect the plasma Ang-1 level,and immunohistochemical method was used to detect the CD1a and CD56 levels in fetal sac tissue.Logistics regression model was used to analyze the relationship between the expression levels of Ang-1,CD1a,and CD56 of the women with medical abortion by mifepristone and their abnormal uterine bleeding.Results:The levels of Ang-1(365.38±32.15 ng/L),CD1A(25.38±5.21%),and CD56(15.81±3.39%)of the women in group A were significant higher than those(258.67±28.91 ng/L,8.65%±2.13%,and 5.68%±1.58%)of the women in group B(P<0.05).The high levels of Ang-1,CD1A,and CD56 expression were the independent risk factors of abnormal uterine bleeding of the women after medical abortion by mifepristone(P<0.05).Conclusion:The levels of Ang-1,CD1a and CD56 the women with abnormal uterine bleeding after medical abortion by mifepristone are abnormally high expression,and the high levels of Ang-1,CD1A,and CD56 expression are all the independent risk factors of their abnormal uterine bleeding occurrence.