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The Influence of Sperm DNA Damage and Semen Homocysteine on Male Infertility

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摘要 Background:To explore the relationship of sperm DNA fragmentation index(DFI),serum and seminal plasma homocysteine(Hcy),and semen parameters in patients with severe spermatogenetic dysfunction.Methods:A total of 77 infertile males treated in our hospital for severe spermatogenetic dysfunction from January 2016 to November 2017 were recruited.The involved patients were divided into two groups:oligozoospermia(SOM group,35 cases)and asthenozoospermia(OAT group,42 cases).The control group(NM group)contained 31 healthy males without reproductive dysfunctions.All the participants involved were tested in the items below:spermatozoa parameters,spermatozoa DFI,serum Hcy level and seminal plasma Hcy level,concentration of seminal plasma malondialdehyde(MDA),and total antioxidant capacity(TAC).Results:Between the SOM group and NM group,there were significantly difference in sperm concentration,motility and vitality,concentration of MDA,and TAC.The spermatozoa DFI and Hcy levels in SOM group were significantly higher than those of the NM group.Sperm DFI was positively correlated with serum Hcy level(r=0.083,P<0.05).Serum Hcy level was negatively correlated with sperm concentration(r=−0.186,P<0.05)and sperm vitality(r=−0.216,P<0.05).The serum Hcy level was not correlated with sperm Hcy level(r=0.103,P>0.05).Conclusions:The elevated Hcy level and spermatozoa DFI may be important factors of the severe spermatogenetic dysfunction,which can be used as semen index to evaluate sperm quality and male fertility.
出处 《Reproductive and Developmental Medicine》 CSCD 2017年第4期228-232,共5页 生殖与发育医学(英文版)
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  • 1刘浩,耿春惠,王维,肖克林,熊礼宽,黄永祥,杨晓玲,李瑾.乙肝病毒对人精液参数和精子DNA完整性的影响[J].中华男科学杂志,2013,19(10):896-898. 被引量:17
  • 2商学军,黄宇烽,李克,李伟,史轶超,刘光辉,洪菊生.L-肉碱治疗附睾结节伴弱精子症初步观察[J].中华男科学杂志,2004,10(9):671-672. 被引量:44
  • 3商学军,王修来,黄宇烽.肉碱与男性生殖[J].中华男科学杂志,2006,12(8):726-729. 被引量:44
  • 4龚秋明,张程立.高同型半胱氨酸血症:研究进展与临床[J].医学信息(西安上半月),2007,20(1):172-174. 被引量:17
  • 5Sonmez M, Yuce A, Turk G. The protective effects of melatonin and Vitamin E on antioxidant enzyme activities and epididymal sperm characteristics of homocysteine treated male rats [ J ]. Reprod Toxicol, 2007,23(2) :226-231.
  • 6Blom H J, Kleinveld HA, Boers GH, et al. Lipid peroxidation and susceptibility of low-density lipoprotein to in vitro oxidation in hyperhomocysteinemia[ J]. Eur J Cliu Invest, 1995,25(3) :149- 154.
  • 7de Lamirande E, Jiang H, Zini A, et al. Reactive oxygen species and sperm physiology[ J]. Rev Reprod, 1997,2(1 ) :48-54.
  • 8Sharma RK, Agarwal A. Role of reactive oxygen species in male infertility[J]. Urology, 1996,48(6) :835-850.
  • 9Hughes CM, Lewis SE, McKelvey-Martin VJ, et al. The effects of antioxidant supplementation during Percoll preparation on human sperm DNA integrity[J]. Hum Reprod, 1998,13(5) :1240- 1247.
  • 10Wallock LM, Tamura T, Mayr CA, et al. Low seminal plasma folate concentrations are associated with low sperm density and count in male smokers and nonsmokers [ J ]. Fertil Steril, 2001,75 ( 2 ) : 252-259.

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