短链脂肪酸在炎症性肠病中的研究进展

Advances in Studies on Short-chain Fatty Acids in Inflammatory Bowel Disease

炎症性肠病(IBD)是由遗传和环境因素共同驱动导致的肠道慢性炎症性疾病。肠道菌群发酵膳食纤维产生的短链脂肪酸(SCFAs)具有抗炎和维持肠道稳态的作用,肠道炎症和低纤维饮食均可导致产SCFAs细菌数量减少,进而影响肠道免疫和代谢调节。本文就SCFAs在IBD中的研究进展作一综述。

Inflammatory bowel disease(IBD)is a chronic inflammatory disease driven by genetic and environmental factors.Short-chain fatty acids(SCFAs),which are produced by fermentation of dietary fiber by intestinal microbiota,have anti-inflammatory effect and are involved in the maintenance of intestinal homeostasis.Intestinal inflammation and low fiber diet can reduce the number of SCFAs-producing bacteria and thereby affecting intestinal immune and metabolic regulation.This article reviewed the advances in studies on SCFAs in IBD.