2015-2019年上海市急性呼吸道感染病例人冠状病毒感染情况分析

Characteristics of human coronavirus infection in acute respiratory infection cases in Shanghai,2015-2019

目的了解上海市急性呼吸道感染病例中人冠状病毒(HCoV)的分布特征,深入了解HCoV的流行规律,为其防控提供科学依据。方法收集2015—2019年上海市急性呼吸道感染监测标本3531份,利用多重PCR技术进行常见呼吸道病原体的检测。结果在3531份标本中,病毒总检出率为39.73%(1403/3531)。其中,HCoV检出率为3.14%(111/3531)。HCoV在急性呼吸道感染病例中的总检出率仅次于流感病毒和人鼻病毒/肠道病毒,流行亚型以HCoV-OC43、HCoV-NL63为主,不同HCoV亚型在人群中呈隔年交替流行的趋势。混合感染发生率高达36.93%(41/111),混合感染病例中的重症比例较高。结论HCoV是上海市急性呼吸道感染的重要病原,应加强急性呼吸道感染病例病原学监测,重点关注HCoV与其他病原的混合感染。

Objective To understand the infection status of human coronavirus(HCoV)in acute respiratory infection cases in Shanghai,and provide scientific basis for prevention and control of human infection with coronavirus.Methods A total of 3531 samples were collected through acute respiratory infection surveillance in Shanghai from 2015 to 2019,and multiplex PCR technology was used to detect common respiratory viruses.Results In the 3531 samples,the virus detection rate was 39.73%(1403/3531).The detection rate of HCoV was 3.14%(111/3531),ranking 3^(rd)after the detection rates of influenza virus and rhinovirus/enteric virus.The spread subtypes were mainly HCoV-OC43 and HCoV-NL63.Different subtypes of HCoV spread alternately in the population every year.The incidence of co-infection was as high as 36.93%(41/111),and the proportion of co-infection in severe cases was high.Conclusion HCoV is an important pathogen of acute respiratory tract infection in Shanghai.It is necessary to strengthen the etiological surveillance in acute respiratory tract infection cases,especially the co-infection of HCoV and other pathogens.