纤维蛋白原、NLR及F-NLR评分在胃癌中的研究进展

Research progress of fibrinogen, NLR and F-NLR grading in gastric cancer

胃癌相关的多种标志物已被广泛用于临床,可预测其发生、发展及预后。血清纤维蛋白原水平及中性粒细胞-淋巴细胞比值(NLR)分别作为凝血系统及炎症的代表性指标,可预测胃癌患者的预后和生存时间。纤维蛋白原水平的升高与胃肿瘤细胞的增殖、侵袭和迁移能力的增强有显著的相关性;高NLR和胃癌患者的生存期缩短密切相关。由二者联合的F-NLR评分结合了两者在预测胃癌的发生、发展和转归中的优点,在胃癌预后预测等方面显示出了良好的应用价值,具有广阔的应用前景。

Multiple markers that related to gastric cancer has been widely used in clinical,to predict its occurrence,development and prognosis.Serum level of fibrinogen(FIB)and neutrophil to lymphocytes ratio(NLR)respectively as representative indicators of coagulation system and inflammation,can predict the prognosis of patients with gastric cancer and survival time.The rise of fibrinogen is associated with enhanced capacity of the gastric tumor cells proliferation,invasion and migration.High NLR is associated with significantly induced survival of patients with gastric cancer.The combination of fibrinogen and NLR(F-NLR)combines the advantages of each individual indicator in predicting the occurrence,development and prognosis of cancer.It has shown a great prognostic potential in gastric cancer,and can be widely applied in prospect.