基于分数低频振幅方法在发作性睡病功能磁共振成像中的应用

Application of fALFF method in functional magnetic resonance imaging of narcolepsy

目的研究静息态核磁功能成像(rs-fMRI)结合分数低频振幅(fALFF)方法在1型发作性睡病静息态脑功能中的应用价值。方法选择80名受试者,其中40名健康人,40例临床诊断为1型发作性睡病患者,进行颅脑静息态磁共振(rs-fMRI)扫描。将扫描后的rs-fMRI数据进行分数低频振幅(fALFF)方法分析,分别得出健康人与1型发作性睡病患者的fALFF图像。结果通过将健康人脑区与患者脑区图像相减,做差值分析得出:在双侧舌回、右侧颞中回、左侧额中回、右额内侧回等脑区1型发作性睡病患者较健康人fALFF值存在改变。结论fALFF方法有利于识别1型发作性睡病患者存在异常的脑区,为其影像学诊断提供了依据。

Objective To study the application value of resting state nuclear magnetic function imaging(rs-fMRI)combined with fractional low frequency amplitude(fALFF)method in resting state brain function of type 1 paroxysmal sleeping disease.Methods Eighty subjects were selected,including 40 normal subjects and 40 patients with type 1 paroxysmal sleeping disease were clinically diagnosed for craniocerebral resting state magnetic resonance(rs-fMRI)scanning.The scanned rs-fMRI data were analyzed by fractional low frequency amplitude(fALFF)method,and the fALFF images of normal people and type 1 paroxysmal sleeping disease patients were obtained respectively.Results By subtracting the images of normal brain area and patient's brain area,the difference analysis showed that there was a change in the fALFF of type 1 paroxysmal sleeping disease in bilateral lingual gyrus,right middle temporal gyrus,left middle frontal gyrus and right medial frontal gyrus.Conclusions fALFF method is helpful to identify the abnormal brain area in patients with type 1 paroxysmal sleeping disease and provide basis for imaging diagnosis.