大动物体外膜氧合模型建立的研究进展

The research progress in the establishment of large animal models with extracorporeal membrane

体外膜氧合(ECMO)是心肺功能衰竭患者通过机械循环辅助装置获得短时间体外生命支持(ECLS)的一种辅助治疗手段。动物模型是ECLS领域研究的基础,基于动物模型可以进行相关生理学研究及分子机制研究,并为相关临床试验提供重要参考。本文旨在对现有的不同ECMO大动物模型的特点和建立方法进行了系统的综述,目的是优化在未来研究设计中模型建立的相关策略。

Extracorporeal membrane oxygenation(ECMO)is an adjuvant therapy for patients with heart or respiratory failure to obtain short-term extracorporeal life support(ECLS)through mechanical circulatory assist device.Animal models are the basis of ECLS research.Based on animal models,we can carry out physiological research and molecular mechanism research,and provide important reference for clinical trials.The purpose of this paper is to systematically review the characteristics and establishment methods of large animal models with ECMO,and to optimize the relevant strategies for model establishment in future research design.