奥司他韦对脓毒血症患者血小板和凝血功能的影响

Effect of Oseltamivir on platelet and coagulation function in patients with sepsis

目的探讨奥司他韦对脓毒血症患者血小板计数及凝血功能的影响。方法选取2018年1月—2020年2月南昌大学第三附属医院收治的59例脓毒血症患者作为研究对象,按照随机数字表法分为对照组(29例)与奥司他韦组(30例),对照组采用常规综合治疗,奥司他韦组采用在常规综合治疗的基础上加用奥司他韦。比较两组患者入科时和治疗后第1、3、5、7天的血小板参数[激活全血凝固时间(ACT)、凝血速率(CR)、血小板计数(PLT)、血小板功能(PF)]和凝血功能指标[血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FBG)]。结果治疗后,奥司他韦组的PLT和PF高于对照组,差异有统计学意义(P<0.05);治疗后,奥司他韦组的ACT、PF、PT、APTT和FBG低于对照组,差异有统计学意义(P<0.05)。两组患者的不良事件总发生率比较,差异无统计学意义(P>0.05)。结论奥司他韦能显著改善脓毒血症患者血小板参数和凝血功能,值得临床推广。

Objective To investigate the effect of Oseltamivir on platelet and coagulation function in patients with pyemia.Methods From January 2108 to February 2020,a total of 59 patients with sepsis admitted to the Third Affiliated Hospital of Nanchang University were selected as the research objects,and divided into the control group(n=29)and the Oseltamivir group(n=30)according to the random number table method.The control group was treated with conventional comprehensive,while the patients in the Oseltamivir group received Oseltamivir on the basis of routine treatment.The platelet parameters(activated clotting time of whole blood[ACT],clot rate[CR],platelet count[PLT],platelet function[PF])and coagulation function indicators(prothrombin time[PT],activated partial prothrombin time[APTT],fibrinogen[FBG])were compared between the two groups when entered the department and 1,3,5,7 days after treatment.Results After the treatment,the PLT and PF of the Oseltamivir group were higher than those of the control group,the differences were statistically significant(P<0.05).After the treatment,the ACT,PF,PT,APTT and FBG of the Oseltamivir group were lower than those of the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the total incidence of adverse events between the two groups(P>0.05).Conclusion Oseltamivir can improve platelet and coagulation function significantly in patients with sepsis,which is worthy of clinical promotion.