三阴乳腺癌中EGFR及VEGFR的表达及与病理特征的相关性分析

Expression of EGFR and VEGFR in triple-negative breast cancer and their correlations analysis with pathological characteristics

目的探讨三阴乳腺癌(TNBC)中表皮生长因子受体(EGFR)及血管内皮生长因子受体(VEGFR)的表达及其与病理特征的相关性。方法回顾性选取2018年3月—2020年3月在佛山市禅城区中心医院行手术治疗的200例乳腺癌患者作为研究对象,其中包括TNBC与非TNBC患者各100例,收集所有患者的临床病理资料,包括年龄、月经状况、病理类型、临床分期、组织学分级、淋巴结转移情况等,收集术后病理组织检测EGFR与VEGFR表达情况,分析其表达差异及其与TNBC临床病理特征之间的关系。结果TNBC组患者EGFR、VEGFR阳性表达率均高于非TNBC组,差异有统计学意义(P<0.05)。TNBC患者EGFR的表达与淋巴结转移相关,而VEGFR的表达与临床分期、组织学分级及淋巴结转移相关(P<0.05)。Spearman相关性分析显示:TNBC患者EGFR与VEGFR的表达之间存在正相关关系(r=0.306,P<0.05)。结论TNBC患者EGFR及VEGFR存在高表达,且其表达与病理特征之间存在相关性,对于评价TNBC的病情及预后有一定的意义。

Objective To investigate the expression of epidermal growth factor receptor(EGFR)and vascular endothelial growth factor receptor(VEGFR)in triple-negative breast cancer(TNBC)and their correlations with pathological characteristics.Methods A total of 200 breast cancer patients who underwent surgeries in Foshan Chancheng Central Hospital from March 2018 to March 2020 were retrospectively selected as the research subjects,including 100 TNBC patients and 100 non-TNBC patients.The clinicopathological data of all patients were collected,including age,menstrual status,pathological type,clinical stage,histological grade,lymph node metastasis,etc.The postoperative pathological tissues were collected to detect the expression of EGFR and VEGFR,and the differences in expression and their correlations with the clinicopathological characteristics of TNBC were analyzed.Results The positive expression rates of EGFR and VEGFR in the TNBC group were higher than those in the non-TNBC group,with statistically significant differences(P<0.05).The expression of EGFR in TNBC patients was related to lymph node metastasis,while the expression of VEGFR was related to clinical stage,histological grade,and lymph node metastasis(P<0.05).Spearman correlation analysis showed that there was a positive correlation between the expression of EGFR and VEGFR in TNBC patients(r=0.306,P<0.05).Conclusion High expression of EGFR and VEGFR are existed in TNBC patients,and there is a correlation between their expression and pathological characteristics,which has certain significance on evaluating the condition and prognosis of TNBC.