不同剂量福莫特罗在中重度慢性阻塞性肺疾病中的应用效果

Application effect of different doses of Formoterol in moderate to severe chronic obstructive pulmonary disease

目的探究不同剂量福莫特罗在中重度慢性阻塞性肺疾病(COPD)中的应用效果。方法选取2019年6月—2020年6月丰城市人民医院收治的84例中重度COPD患者作为研究对象,采用随机数字表法分为甲组(42例)与乙组(42例)。甲组采用常规剂量福莫特罗治疗,乙组采用双倍剂量福莫特罗治疗。比较两组的肺功能[第一秒用力呼气容积(FEV1)及FEV1占预计值百分比(FEV1%)和FEV1/用力肺活量(FVC)]、血管内皮功能[血管内皮生长因子(VEGF)、内皮素-1(ET-1)、一氧化氮(NO)]和不良反应总发生率。结果治疗前后,两组FEV1、FEV1%和FEV1/FVC比较,差异无统计学意义(P>0.05)。治疗后,两组FEV1%和FEV1/FVC水平高于本组治疗前,差异有统计学意义(P<0.05)。治疗前后,两组VEGF、ET-1、NO比较,差异无统计学意义(P>0.05)。治疗后,两组VEGF、NO水平高于本组治疗前,ET-1水平低于本组治疗前,差异有统计学意义(P<0.05)。乙组不良反应总发生率高于甲组,差异有统计学意义(P<0.05)。结论对中重度COPD患者采用福莫特罗治疗,治疗效果显著,大剂量的福莫特罗会增加不良反应的发生率。

Objective To explore the application effect of different doses of Formoterol in moderate to severe chronic obstructive pulmonary disease(COPD).Methods A total of eighty-four moderate and severe COPD patients admitted to Fengcheng People′s Hospital from June 2019 to June 2020 were selected as the research subjects and divided into group A(42 cases)and group B(42 cases)by random number table method.Group A was treated with conventional dose of Formoterol,and group B was treated with double dose of Formoterol.The lung function(forced expiratory volume in the first second[FEV1]and FEV1 as a percentage of predicted value[FEV1%]and FEV1/forced vital capacity[FVC]),endothelial function(vascular endothelial growth factor[VEGF]and endothelin-1[ET-1],nitric oxide[NO])and the total incidence of adverse reactions of two groups were compared.Results Before and after treatment,there were no significant differences in FEV1,FEV1%and FEV1/FVC between the two groups(P>0.05).After treatment,FEV1%and FEV1/FVC levels in both groups were higher than those before treatment,with statistical significance differences(P<0.05).Before and after treatment,there were no significant differences in VEGF,ET-1 and NO between the two groups(P>0.05).After treatment,the levels of VEGF,and NO in both groups were higher than those before treatment,ET-1 level was lower than that before treatment,the differences were statistically significant(P<0.05).The total incidence of adverse reactions in group B was higher than that in group A,and the difference was statistically significant(P<0.05).Conclusion Formoterol treatment for patients with moderate to severe COPD has significant therapeutic effects.Large doses of Formoterol will increase the incidence of adverse reactions.