丹参川芎嗪治疗慢性心力衰竭的效果

Effect of Danshen Ligustrazine on chronic heart failure

目的探讨丹参川芎嗪治疗慢性心力衰竭的效果。方法选取2019年1月—2020年8月江门市五邑中医院收治的78例慢性心力衰竭患者作为研究对象,根据随机数字表法将其分为对照组与观察组,每组各39例。对照组患者采用常规对症治疗,观察组患者在对照组的基础上加用丹参川芎嗪。比较两组患者的疗效、心功能指标、血清炎症因子、神经内分泌激素水平。结果观察组患者的临床总有效率(94.87%)高于对照组(79.49%),差异有统计学意义(P<0.05)。治疗后,观察组患者的左心室舒张末容量(LVEDV)、左心室收缩末容量(LVESV)、左室舒张末期前后径(LVEDD)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、醛固酮(ADL)、血浆肾素(PRA)、血管紧张素Ⅱ(AngⅡ)、去甲肾上腺素(NE)及血清氨基末端脑钠肽前体(NT-proBNP)水平均低于对照组,左心室射血分数(LVEF)、白细胞介素-10(IL-10)水平高于对照组,差异有统计学意义(P<0.05)。结论采用丹参川芎嗪辅助治疗慢性心力衰竭患者,可以改善心功能指标,通过调节血清中炎症因子水平与神经内分泌激素水平,起到减轻心肌能量消耗、提高治疗效果的作用。

Objective To explore the effect of Danshen Ligustrazine in the treatment of chronic heart failure.Methods A total of 78 patients with chronic heart failure admitted to Wuyi Traditional Chinese Medicine Hospital of Jiangmen City from January 2019 to August 2020 were selected as the research objects and divided into the cintrol group and the observation group according to the random number table method,with 39 cases in each group.The control group received routine symptomatic treatment,and the observation group was treated with Danshen Ligustrazine in the basis of the cintrol group.The clinical efficacy,cardiac function,serum inflammatory factors,and neuroendocrine hormone levels of the two groups were compared.Results The total clinical effective rate of the observation group(94.87%)was higher than that of the control group(79.49%),and the difference was statistically significant(P<0.05).After treatment,the left ventricular end diastolic volume(LVEDV),left ventricular end systolic volume(LVESV),left ventricular end diastolic anteroposterior diameter(LVEDD),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),aldosterone(ADL),plasma renin(PRA),angiotensinⅡ(AngⅡ),norepinephrine(NE)and serum N-terminal pro-brain natriuretic peptide(NT-proBNP)of the observation group were lower than those of the control group,the levels of left ventricular ejection fraction(LVEF)and interleukin-10(IL-10)were higher than those of the control group,and the differences were statistically significant(P<0.05).Conclusion Adjuvant treatment of patients with chronic heart failure with Danshen Ligustrazine can improve heart function indicators,reduce myocardial energy consumption and improve the therapeutic effect by regulating the levels of serum inflammatory factors and neuroendocrine hormones.