低频与高频重复经颅磁刺激治疗小儿抽动症的疗效观察

Low Frequency and High Frequency Repeated Transcranial Magnetic Stimulation in the Treatment of Children with Tourette Syndrome

目的探讨低频与高频重复经颅磁刺激治疗小儿抽动症的疗效。方法选取2017年1月至2018年12月我院收治的45例小儿抽动症患儿,对患儿辅助运动区进行低频与高频重复经颅磁刺激(根据患儿病症情况,选用1 Hz低频刺激或者10 Hz高频刺激),对比患儿在治疗前、治疗后的抽动严重程度,观察该方法的治疗效果(YGTSS评分、CGI评分)、不良反应、静息阈值(resting motor threshold,RMT)。结果治疗后患儿静息阈值上升,YGTSS评分下降,CGI评分上升,差异具有统计学价值(P<0.05)。治疗后患儿无明显不良反应。结论低频与高频重复经颅磁刺激治疗小儿抽动症效果明显,在治疗后患儿的临床症状明显改善。

Objective To investigate the efficacy of low frequency and high frequency repeated transcranial magnetic stimulation in the treatment of children with tourette syndrome.Methods Between January 2017 and December 2018,45 cases of our hospital between children with infantile tourette syndrome in children with auxiliary motor area of low frequency and high frequency repetitive transcranial magnetic stimulation(according to the situation of children with symptoms,choose 1 Hz low frequency stimulation or high frequency stimulation 10 Hz),contrast before and after treatment in children with tic severity,observe the treatment effect of the method(YGTSS score,CGI score),side effects,resting threshold(resting motor threshold,RMT).Results After treatment,the resting threshold of the children was increased,the YGTSS score was decreased,and the CGI score was increased,the difference is statistically significant(P<0.05).The child had no obvious adverse reactions after treatment.Conclusion Low frequency and high frequency repeated transcranial magnetic stimulation is effective in the treatment of children with tourette syndrome.