海洛因成瘾的遗传学研究进展

Research Advances in Genetics of Heroin Addiction

海洛因成瘾机制复杂多变,受遗传、环境、社会等多种因素影响,其中遗传因素是最重要的影响因素之一。随着遗传学研究方法的进展,人们发现除多巴胺能神经系统和单胺能神经系统相关基因外还有更多的基因多态性与海洛因成瘾易感性相关,本文就近年来新鉴定出的与海洛因成瘾相关的基因及其多态位点进行综述,以期为海洛因成瘾的机制研究以及成瘾标志物和治疗靶点的探索提供新思路。

Heroin addiction has complex mechanisms and is influenced by many factors such as heredity,environment and society,among which heredity is one of the most important factors.With the development of genetic approaches,more and more genetic polymorphisms are found to be associated with heroin addic-tion in addition to the dopaminergic and monoaminergic neuron genes.Herein,newly identified genes and their polymorphic loci related to heroin addiction are reviewed in hope of providing new thinking for mecha-nisms of heroin addiction and the exploration of addiction markers and therapeutic targets.