多模态影像技术在帕金森病冻结步态中的研究进展

Research progress of multi-modal imaging techniques in Parkinson's disease with freezing of gait

冻结步态(freezing of gait,FOG)是帕金森病(Parkinson's disease,PD)的一种常见症状,主要表现为突然的步行中断和严重的运动困难[1]。FOG使得患者摔倒的风险增加,生活质量下降。前期研究采用多模态影像技术对伴有FOG的PD患者的脑功能和结构的改变进行了研究,为了进一步分析这些影像学改变与FOG严重程度之间的关系,笔者对多模态影像技术在PD患者FOG诊疗方面的研究进展进行综述。

Freezing of gait(FOG)is a common paroxysmal gait disorder in Parkinson's disease(PD).FOG manifests as sudden interruption in walking and severe movement difficulties,which increases the risk of falling and declines the quality of life.However,the neuropathophysiological mechanism of PD-FOG is still unclear.The previous study uses multi-modal imaging techniques to the changes in the brain function and structure of PD patients with or without FOG,and links these findings with the severity of FOG.This article reviews the research progress of multimodal imaging technology in the diagnosis and treatment of PD patients with FOG.