水通道蛋白4与缺血性脑卒中的相关性及影像学研究进展

Relationship between aquaporin-4 and ischemic stroke and imaging research progress

以急性缺血性脑卒中为主要类型的脑卒中已成为全球第二大致死、致残疾病,早期及时的诊断与治疗对患者的预后至关重要。近年来,随着对水通道蛋白的研究逐渐深入,研究人员发现水通道蛋白4与缺血性脑卒中密切相关,并且提出以水通道蛋白理论为基础的磁共振成像检查技术用于缺血性脑卒中检查。笔者对水通道蛋白4与缺血性脑卒中的关系以及水通道蛋白成像在缺血性脑卒中的技术进展进行综述。

Acute ischemic stroke as the main type of stroke has become the second largest cause of death and disability in the world.Early and timely diagnosis and treatment is very important to the prognosis of patients.In recent years,with the in-depth study of aquaporin,researchers found that aquaporin 4 is closely related to ischemic stroke,and proposed magnetic resonance imaging based on aquaporin theory.This article reviews the relationship between aquaporin 4 and ischemic stroke and the technical progress of aquaporin imaging in ischemic stroke.