壳聚糖载药阿司匹林复合纤维的制备及其释药性能

Aspirin loaded chitosan based composite fiber and its release performance

为研制具有缓释效果的解热镇痛材料,以阿司匹林(Asp)为模型药剂、壳聚糖(CS)为纺丝基材、聚丙烯酸钠(PAAS)为助纺高分子,采用静电纺丝和热处理制备了Asp-CS/PAAS复合纤维材料;研究了热处理温度对复合纤维微观形貌、化学结构、力学性能以及体外释药行为的影响。结果表明:以10wt%的聚丙烯酸钠作为共纺高分子可以形成直径约886 nm的纤维,热处理温度的提高可以提高纤维的耐溶剂性能,但会降低纤维的拉伸强度;进一步的研究结果表明简单的热处理可以调控纤维的溶胀性能,从而实现调节阿司匹林药物的释放速率,缓释曲线符合Higuchi模型。

For the development of analgesic analgesia material with sustained release performance,aspirin loaded chitosan(CS)/sodium poly(acrylic acid)(PAAS)composite fiber was prepared by electrospinning and heat treatment.The influence of heat treatment temperature on solvent resistance,chemical stability,tensile strength and in vitro drug release performance was investigated.The results show that aspirin loaded CS/PAAS composite fiber with mean diameter of 886 nm can be achieved with 10wt.%of PAAS loading.Increasing the heat treat temperature can improve the solvent resistance of fiber,but reduce the tensile strength.The heat treatment temperature can adjust the swelling properties of the composite nanofibers in PBS solution,which can then affect the in vitro release performance.