磁性Janus纳米材料的合成及生物性能研究

Synthesis and biological properties of magnetic janus nanomaterials

纳米药物载体在药物输送系统中发挥着极其重要的作用,其中Janus纳米材料因其具有各向异性的特点,能提高药物载体的载药率、靶向性等,成为研究者关注的焦点之一。本实验通过种子异向生长法,以球型磁性Fe_(3)O_(4)为内核,在其表面异向生长出棒状介孔二氧化硅,得到球-棒结构的磁性Janus纳米材料(Magnetic Janus Nanomaterials)。在磁性Janus纳米复合材料修饰前后对于布洛芬的搭载及体外释放试验中,发现氨基修饰的磁性Janus纳米复合材料载药率较大且具有缓释的作用。经血液相容性实验发现该材料在200μg·mL^(-1)浓度以下时,溶血率小于5%。

Nano drug carriers play an extremely important role in drug delivery systems.Janus nanomaterials have the characteristics of anisotropy,which can improve the drug loading rate and targeting of drug carriers,so it has become one of the focuses of researchers.In this experiment,spherical magnetic Fe_(3)O_(4) was used as the core,and rod-shaped mesoporous silica was grown anisotropically on the surface through seed anisotropy growth method to obtain magnetic Janus nanomaterials with a ball-rod structure.In the loading and in vitro release tests of ibuprofen before and after the modification of the magnetic Janus nanocomposite,it was found that the amino-modified magnetic Janus nanocomposite has a high drug loading rate and a sustained release effect.The blood compatibility experiments found that the material under 200μg·mL^(-1) concentration,the hemolysis rate of less than 5%.