摘要
Objective:To systematically evaluate the efficacy of Traditional Chinese medicine for improving bone damage in rheumatoid arthritis(RA),and provide guidance for clinical treatment.Methods:computer retrieval China hownet database(CNKI),Chinese biomedical literature retrieval(SinoMed),ten thousand Data knowledge service system(WanFang Data),VIP full-text database(VIP),PubMed,MedLine and the cochrane library,collect relevant Chinese medicine for the treatment of rheumatoid arthritis,bone destruction randomized controlled trial(RCT),screening from built by researchers at the two libraries to literature in February 2020,to extract the required indicators,and incorporated into RevMan 5.2 analysis.Results:a total of 1291 patients were included in 14 RCTS.The results of meta-analysis showed that compared with the control group,The traditional Chinese medicine treatment group could improve the 25-hydroxyvitamin D of patients with RA bone damage,which was better than the western medicine control group,and the difference was statistically significant.TCM treatment group can improve the balance between osteoblasts and osteoclasts(nuclear factor B receptor activating factor;Bone mineral density;Bone alkaline phosphatase;Bone protectin;(osteocalcin),and was superior to the western medicine control group,the difference was statistically significant;(3)traditional Chinese medicine treatment group can improve RA patients with bone destruction of the balance of osteoblast and osteoclast(Ⅰtype collagen amino terminal propeptide before;Carboxy-terminal peptide of collagen;The effect of nuclear factor B receptor activator factor and bone protectin was similar to that of the western medicine control group,and the difference was not statistically significant.Conclusion:At present,the existing evidence can prove that Traditional Chinese Medicine in the treatment of rheumatoid arthritis bone damage has an exact effect,regulate the function of osteoblasts and osteoclasts,improve the level of bone metabolism of patients,prevent the progress of bone damage.
基金
Ministry of Science and Ttechnology National Key R&D Program Key Project of TCM Modernization Research(No.2018YFC1705204)
General projects of NSFC(No.81973655)
Foreign Science and Technology Cooperation Projects of Anhui Provincial Key Research and Development Plan(No.201904b11020011)
Anhui Provincial Quality Engineering Teaching Research Project(No.2018jyxm1068)
Construction Project of Famous TCM Liu Jian studio in Anhui Province(No.2018-11)
National Training Program for Innovative Talents of Traditional Chinese Medicine(No.2019-128)
Key Research and Development Projects in Anhui Province(No.201904a07020004)Anhui Provincial Laboratory of Applied Foundation and Development of Modern Internal Medicine of Traditional Chinese Medicine(No.2016080503B041)
The 12th Batch of"115"Innovation Teams in Anhui Province(No.2019-1)。
