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p 16/Ki 67双染在宫颈病变患者筛查中的价值 被引量:1

Value of p 16/Ki 67 double staining in screening cervical lesions
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摘要 目的探究p16/Ki67免疫染色在宫颈病变患者筛查中的价值。方法选择2017年1月至2020年1月在深圳市宝安区福永人民医院就诊的宫颈病变患者80例为研究对象,采集细胞标本进行p16/Ki67双染和人乳头瘤病毒(HPV)检测,计算两种检测方法在宫颈病变诊断中的敏感性和特异性。结果80例研究对象中p16/Ki67检测显示阳性者共45例,意义不明的不典型鳞状细胞(ASC-US)、不能排除高度上皮内病变的不典型鳞状上皮(ASC-H)、低度鳞状上皮内病变(LSIL)和高度鳞状上皮内病变(HSIL)分级患者中p16/Ki67阳性比例分别为45.76%(27/59)、75.00%(3/4)、85.71%(12/14)和100.00%(3/3),宫颈病变越严重,p16/Ki67检测阳性率越高(P<0.05);HPV阳性共54例,ASC-US、ASC-H、LSIL和HSIL分级患者中HPV阳性比例分别为66.10%(39/59)、50.00%(2/4)、71.43%(10/14)和100.00%(3/3),不同宫颈病变分级患者的HPV阳性率间差异无统计学意义(P>0.05);p16/Ki67双染诊断LSIL及以上病变的敏感性为88.24%,特异性为52.38%,HPV检测的敏感性为76.47%,特异性为34.92%,p16/Ki67和HPV检测的敏感性间差异无统计学意义(P>0.05),特异性间差异有统计学意义(P<0.05)。结论p16/Ki67阳性率与宫颈病变程度有关,p16/Ki67染色对宫颈癌病变诊断的敏感性和特异性较高,临床上可用于宫颈癌筛查的辅助诊断,值得推广应用。 【Objective】To explore the value of p 16/Ki 67 immunostaining in screening cervical lesions.【Methods】Eighty patients with cervical lesions in our hospital from January 2017 to January 2020 were selected as the research objects.Cell samples were collected for p 16/Ki 67 double staining and HPV detection,and the sensitivity and specificity of the two detection methods in the diagnosis of cervical lesions were calculated.【Results】There were 45 cases of p 16/Ki 67 positive,and the positive rates of p 16/Ki 67 in ASC-US,ASC-H,LSIL and HSIL were 45.76%(27/59),75.00%(3/4),85.71%(12/14)and 100.00%(3/3),respectively.The more serious the cervical lesions,the higher the positive rate of p 16/Ki 67(P<0.05).There were 54 cases of HPV positive,and HPV positive in ASC-US,ASC-H,LSIL and HSIL was 66.10%(39/59),50.00%(2/4),71.43%(10/14)and 100.00%(3/3),respectively.There was no significant difference in the positive rate of HPV among patients with different grades of cervical lesions(P>0.05).The sensitivity and specificity of p 16/Ki 67 double staining in the diagnosis of LSIL and above lesions were 88.24%,52.38%,which were 76.47%,34.92%of HPV detection.There was no significant difference in the sensitivity(P>0.05),but there was significant difference in the specificity between p 16/Ki 67 and HPV detection(P<0.05).【Conclusion】The positive rate of p 16/Ki 67 is related to the degree of cervical lesions.The sensitivity and specificity of p 16/Ki 67 staining in the diagnosis of cervical cancer is high.It can be used in the auxiliary diagnosis of cervical cancer screening in clinical practice,which is worthy of promotion and application.
作者 陈春燕 张仁超 王少晓 CHEN Chunyan;ZHANG Renchao;WANG Shaoxiao(Department of Pathology,Fuyong People's Hospital,Bao'an District,Shenzhen,Guangdong 518000,China;Department of Pathology,Shenzhen Hospital,University of Chinese Academy of Sciences,Shenzhen,Guangdong 518000,China)
出处 《中国医学工程》 2021年第8期74-76,共3页 China Medical Engineering
关键词 P16 KI67 人乳头瘤病毒 宫颈筛查 应用价值 p 16 Ki 67 HPV cervical screening application value
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