摘要
骨关节炎是临床上常见的一种退行性疾病,其引起的关节疼痛与活动障碍严重影响患者的生活质量,然而骨关节炎发病机制目前尚未完全清楚。细胞周基质(pericellular matrix,PCM)是软骨细胞周围狭窄的基质区域,近年来大量研究揭示了PCM在骨关节炎发病机制中的促进作用。PCM成分的降解、生长因子的释放以及机械信号转导的改变,加速了骨关节炎的发生和发展。该文总结了PCM的组成与功能,并对PCM介导骨关节炎发生发展的最新研究进展进行综述。
Osteoarthritis(OA)is one of the most common degenerative diseases in clinic.It causes joint pain and dyskinesia,and seriously affects the quality life of the patients′.However,the pathogenesis of OA has not been fully understood.Pericellular matrix(PCM)is a narrow matrix area around chondrocytes.Numerous evidences have revealed the promotion of PCM in the pathogenesis of osteoarthritis.The degradation of PCM components,the release of growth factor and the alteration of mechanical signal transduction accelerate the occurrence and development of OA.This paper summarizes the structure and functions of PCM,and reviews the latest progresses in the involvement of PCM in OA pathogenesis.
作者
胡文成
朱弘一
林俊卿
郑宪友
HU Wen-cheng;ZHU Hong-yi;LIN Jun-qing;ZHENG Xian-you(Department of Orthopedic Surgery,Shanghai Sixth People's Hospital,Shanghai Jiao Tong University,Shanghai 200233,China)
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2021年第8期1089-1093,共5页
Journal of Shanghai Jiao tong University:Medical Science
基金
国家自然科学基金(81974331,81672144)。
关键词
骨关节炎
细胞周基质
软骨单位
机械转导
osteoarthritis(OA)
pericellular matrix(PCM)
chondron
mechanotransduction
