摘要
肺炎链球菌(Streptococcus pneumoniae,Sp)是社区获得性肺炎以及侵袭性疾病如脑膜炎和败血症的主要致病菌之一,到目前为止,关于肺炎链球菌感染性疾病的预防仍以肺炎链球菌多糖疫苗(pneumococcal polysaccharide vaccine,PPV)和肺炎链球菌多糖蛋白结合疫苗(pneumococcal conjugate vaccine,PCV)为主。然而靶向特定荚膜多糖的肺炎链球菌疫苗的选择性压力在一定程度上诱导了肺炎链球菌荚膜转换,导致了不同荚膜抗原突变体的产生,进而造成非疫苗血清型(non-vaccine type,NVT)及无荚膜肺炎链球菌(nonencapsulated streptococcus pneumoniae,NESp)的增加,使现有的疫苗不能有效预防肺炎链球菌的感染。本文重点介绍了肺炎链球菌非疫苗血清型的发生机制,为制备新型肺炎链球菌疫苗提供思路与策略。
Streptococcus pneumoniae is one of the main pathogens causing community-acquired pneumonia and invasive diseases such as meningitis and septicemia.To date,pneumococcal polysaccharide vaccines and pneumococcal conjugate vaccines remain the main methods to prevent Streptococcus pneumoniae infection.However,selective pressure on Streptococcus pneumoniae vaccines targeting specific capsular polysaccharide induces capsule switching to some extent,thus resulting in the production of mutants expressing different capsular antigens,and leading to an increase in non-vaccine types and nonencapsulated Streptococcus pneumoniae.Consequently,the existing vaccines cannot effectively prevent Streptococcus pneumoniae infection.This article focuses on the mechanisms of non-vaccine serotypes of Streptococcus pneumoniae,to provide ideas and strategies for the preparation of new vaccines for Streptococcus pneumoniae.
作者
刘福莉
李佳茵
何平
华允芬
LIU Fu-li;LI Jia-yin;HE Ping;HUA Yun-fen(College of pharmacy,Zhejiang University of Technology,Hangzhou 310014,China;Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)
出处
《中国人兽共患病学报》
CAS
CSCD
北大核心
2021年第8期734-740,747,共8页
Chinese Journal of Zoonoses
基金
浙江省自然科学基金项目(No.LQ12C02003)。
关键词
肺炎链球菌
荚膜多糖
非疫苗血清型
无荚膜肺炎链球菌
疫苗
Streptococcus pneumoniae
capsular polysaccharide
non-vaccine serotypes
nonencapsulated Streptococcus pneumoniae
vaccine