类风湿关节炎患者合并骨质疏松的影响因素分析

Andysis of the Influencing Factors of Rheumatoid Arthritis Complicated with Osteoporosis

目的探究类风湿关节炎(rheumatoid arthritis,RA)患者合并骨质疏松(osteoporosis,OP)的影响因素。方法71例RA患者与31例健康人,分别收集不同组的个人资料、实验室检查、骨密度等,并计算出RA患者的DAS28-ESR结果,采用多因素Logistic回归分析RA合并OP发生的影响因素。结果RA患者与健康人相比较骨密度测量值整体偏低,更易发生骨质疏松。多因素Logistic回归分析得出RA合并OP的独立危险因素是高龄、长病程、高滴度亮氨酸氨基肽酶、升高的DAS28-ESR(OR=1.153、1.096、1.177、5.421,P<0.05),差异有统计学意义(P<0.05)。结论RA患者如存在高龄、长病程、高级别疾病活动度等危险因素时,尤其患者体内存在高滴度的亮氨酸氨基肽酶时,应警惕该患者是否合并骨质疏松。

Objective To explore the influencing factors of rheumatoid arthritis(RA)combined with osteoporosis(OP).Methods 71 RA patients and 31 healthy people were selected.The data including personal data,laboratory tests and bone mineral density of different groups was collected.DAS28-ESR results of RA patients were calculated.Multivariate Logistic regression was used to analyze the influencing factors of RA complicated with OP.Results Compared with healthy people,RA patients had lower bone mineral density and were more prone to osteoporosis.Multivariate Logistic regression analysis showed that the independent risk factors for RA complicated with OP were advanced age,long course of disease,high titer of leucine aminopeptidase,and elevated DAS28-ESR(OR=1.153,1.096,1.177,5.421,P<0.05),with statistically significant difference(P<0.05).Conclusion If RA patients have risk factors such as advanced age,long course of disease,and high level of disease activity,especially if there is high titer of leucine aminopeptidase in the body,we should be alert to whether the patient is complicated with osteoporosis.