阻塞性睡眠呼吸暂停对记忆巩固的影响及机制

Effect and underlying mechanism of obstructive sleep apnea on memory consolidation

本文目的是梳理阻塞性睡眠呼吸暂停(OSA)对记忆巩固影响的相关研究进展,推测其所涉机制,为探索可逆转OSA记忆巩固障碍的治疗措施提供参考。目前研究认为,轻度OSA可致不同类型记忆巩固效应损伤,且发现这些损伤与多导睡眠监测多个指标(如睡眠微结构、呼吸暂停低通气指数、觉醒指数等)密切相关,推测睡眠结构的破坏及间歇性缺氧所致的睡眠依赖性记忆巩固相关脑区和神经通路损伤可能引发记忆巩固效应的衰退。长期持续正压通气治疗可缓解OSA的记忆巩固损伤,但其他干预方法的效果还未可知。

The purpose of this paper is to review the research progress on the effects of obstructive sleep apnea(OSA)on memory consolidation,and to speculate on possible mechanisms underlying these effects,so as to inform the exploration of effective therapeutic measures for impaired memory consolidation.Previous studies have shown that mild OSA may impair different types of memory consolidation,and the impairments are closely related to certain indices of polysomnography(such as sleep microstructure,apnea hypopnea index,arousal index,etc).Therefore,it is hypothesized that disruption of sleep architecture and damage to brain regions and neural pathways associated with sleep-dependent memory consolidation due to intermittent hypoxia may trigger a decline in memory consolidation.Meantime,long-term continuous positive airway pressure can alleviate the impairment of memory consolidation induced by OSA,but whether other interventions can mitigate the damage remains unclear.