中性粒细胞/淋巴细胞比值在下肢动脉硬化闭塞症中的研究进展

Research progress of neutrophil/lymphocyte ratio in lower extremity arteriosclerosis obliterans

动脉循环中的炎症被认为是动脉粥样硬化斑块发展的一个因素。过去几十年中,通过测量血清生化标志物来量化持续炎症程度的尝试一直在进行。中性粒细胞/淋巴细胞比值作为下肢动脉硬化闭塞症(ASO)有效的炎症预测因子已得到越来越多学者的关注,在下肢ASO患者中适当使用生物标志物可能有助于早期诊断,增强对疾病发展过程的了解,并改进现有疗法和开发新疗法。

Inflammation in the arterial circulation is considered to be a risk factor for the development of atherosclerotic plaques.In the last several decades,attempts have been made to quantify the degree of ongoing inflammation through measurement of serum biochemical markers.Neutrophil/lymphocyte ratio as an effective inflammatory predictor in lower extremity arteriosclerosis obliterans(ASO)has attracted more and more attention.Appropriate application of biomarkers in patients with ASO may contribute to an early diagnosis,a better understanding of disease progression,as well as to the subsequent improvement of current therapies and development of new ones.