不同类型重度子痫前期患者脐动脉血HSP70表达与胎儿出生状况及短期预后的关系

Relationship between the expression of HSP70 in umbilical artery blood and fetal birth status and short⁃term prognosis in patients with different types of severe preeclampsia

目的探讨不同类型重度子痫前期患者脐动脉血HSP70表达与胎儿出生状况及短期预后的关系。方法选取剖宫产分娩且35周≤孕龄≤36周的重度子痫前期孕妇60例为研究对象,早发型和晚发型各30例,选择同期单纯早产孕妇30例为对照组。记录各组胎儿娩出后的出生状况、短期预后及转归,检测母体血清、脐动脉血中HSP70水平。结果低出生体重儿发生率为早发型组(63.33%)>晚发型组(48.33%)>对照组(29.67%),组间比较差异均有统计学意义(均P<0.05);早发型组新生儿出生1 min和5 min的Apgar评分均低于晚发型组和对照组(均P<0.05),三组母体循环及脐带血HSP70水平均为早发型组>晚发型组>对照组(均P<0.05),三组新生儿转入NICU的比例、NICU住院时长及总住院时长均为早发型组>晚发型组>对照组(均P<0.05)。结论重度子痫前期患者脐动脉血中HSP70表达水平与疾病严重程度及胎儿出生状况密切相关,其可能是反映重度子痫前期患者胎儿发育状况的良好指标。

Objective To investigate the relationship between the expression of HSP70 in umbilical artery blood and fetal birth status and short⁃term prognosis in patients with different types of severe preeclampsia.Methods The research subjects were 60 pregnant women with severe preeclampsia who underwent cesarean section,including 30 early⁃onset and 30 late⁃onset patients,and 30 cases of simple premature women were selected as the control group.The birth status,short⁃term prognosis were recorded.ELISA was used to detect HSP70 levels in serum and umbilical artery blood,and the correlation was analyzed.Results The incidence of low birth weight infants was early⁃onset group(63.33%)>late⁃onset group(48.33%)>control group(29.67%)(P<0.05),the Apgar scores of the early⁃onset group at 1 min and 5 min after birth were lower than those of the late⁃onset group and the control group(P<0.05).The levels of HSP70 in maternal circulation and umbilical cord blood were early⁃onset group>late⁃onset group>control group(P<0.05).The proportion of newborns transferred to NICU,the length of stay in NICU and the total length of stay in hospital were early⁃onset group>late⁃onset group>control group(P<0.05).Conclusion In patients with severe preeclampsia,the expression of HSP70 in umbilical artery blood is closely related to the severity of disease and fetal birth status,suggesting that it may be a good indicator of fetal development status.