柴胡桂枝干姜汤治疗胆热脾虚型复发性口腔溃疡的临床观察

Effect of Chaihu⁃Guizhi⁃Ganjiang decoction on recurrent oral ulcers

目的探讨柴胡桂枝干姜汤治疗胆热脾虚型复发性口腔溃疡(recurrent oral ulcer,ROU)的临床疗效和安全性。方法86例胆热脾虚型ROU患者按照随机数字表法分为观察组和对照组,观察组46例予柴胡桂枝干姜汤煎剂口服,对照组40例予康复新液含漱联合维生素B2片口服,两组疗程均为28 d。治疗7 d后对比两组患者疼痛消失时间、口腔溃疡愈合时间及便溏改善情况,随访疗程结束后12个月期间的复发率。结果观察组患者总有效率为84.78%,对照组为72.5%,差异有统计学意义(P<0.05);两组在溃疡疼痛消失时间、溃疡愈合时间比较,差异无统计学意义(P>0.05);观察组便溏恢复正常的比率明显高于对照组,差异有统计学意义(P<0.05);分别在疗程结束后1、3、6、12个月对两组患者进行随访,观察组的复发率显著低于对照组,差异有统计学意义(P<0.05)。结论柴胡桂枝干姜汤能安全和有效治疗胆热脾虚型ROU,并能降低治疗后1年内复发率。

Objective To observe the clinical effects and safety of Chaihu⁃Guizhi⁃Ganjiang decoction for treating recurrent oral ulcer(ROU).Methods A total of 86 outpatients,meeting the diagnostic criteria of ROU and the Chinese medical syndrome pattern of gallbladder⁃heat with spleen⁃deficiency were assigned to two groups by the random number table.The observation group with 46 participants took Chaihu⁃Guizhi⁃Ganjiang decoction orally.The control group of 40 cases gargled Kangfuxin liquid combined with oral administration of vitamin B2 tablets.The two groups both received their treatments for 4 weeks.The sore terminating time and the healing time of oral ulcer wound were recorded after 7 days of treatment,so were the ratios of qualitative variation of feces as well as the recurrence rates in 12 months after the 4⁃week⁃treatment period.Results The overall response rate of the observation group was significantly higher than that of the control group(84.78%vs.72.5%,P<0.05).There were no significantly statistical differences between the two groups concerning the average time of sore terminating and the healing time of oral ulcer wound(P>0.05).The ratio of improved semiliquid stool in the observation group was statistically significantly higher than the control group(P<0.05).The recurrence rates recorded from the follow⁃ups at 1st month,3rd month,6th month and 12th month,were al significantly lower than the control group,respectively(P<0.05).Conclusion Chaihu⁃Guizhi⁃Ganjiang Decoction is effective and safe in the treatment of the ROU and it helps to reduce the recurrence rate within 1 year after a treatment period as well.