白藜芦醇在子痫前期中的作用机制及研究进展

The Mechanism and Research Progress of Resveratrol in Pre-eclampsia

子痫前期是起源于胎盘功能障碍的全身炎性多系统综合征,严重威胁母婴健康。白藜芦醇(Resveratrol)是一种抗衰老、抗氧化应激、抗炎、诱导细胞凋亡和增强胰岛素敏感性的天然多酚化合物。研究表明,白藜芦醇通过抑制氧化应激,抵抗炎症,调节血管功能,促进滋养细胞侵袭,调节免疫功能等在子痫前期的病理生理过程中发挥有效作用。综述白藜芦醇在子痫前期的潜在作用机制及其研究进展,为白藜芦醇进一步在子痫前期的研究和应用提供参考。

Pre-eclampsia is a systemic inflammatory multi-system syndrome originating from placental dysfunction,which seriously threatens the health of both mothers and infants.Resveratrol is a natural polyphenol compound that shows effects on anti-aging,anti-oxidative stress,anti-inflammatory,inducing cell apoptosis and enhancing insulin sensitivity.Resveratrol plays an effective role in the pathophysiological process of pre-eclampsia by inhibiting oxidative stress,resisting inflammation,regulating vascular function,promoting trophoblast cell invasion,and regulating immune function.This article summarizes the potential therapeutic mechanism of Resveratrol in pre-eclampsia,and provides reference for the further research and application of Resveratrol in pre-eclampsia.