O-glycosylation in liver cancer:Clinical associations and potential mechanisms 被引量：1

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摘要 Liver cancer can be an aggressive disease,and is highly prevalent in Asia and Africa.However,its currently approved therapeutic strategies are far from satisfactory.Recent progress in genomic,proteomic and glycomic profiling technologies have enabled the identification of biomarkers that significantly correlate with clinical outcomes.Many biomarkers are related to O-glycosylation of glycoproteins,which belong to an important but less-explored field of liver cancer biology.Here,we review these clinical studies and discuss potential underlying mechanisms.

作者 Kung-Hao Liang Chau-Ting Yeh

机构地区 Liver Research Center Medical Research Department Molecular Medicine Research Center

出处《Liver Research》 2017年第4期193-196,共4页 肝脏研究（英文）

基金 This project was supported by Chang Gung Medical Foundation(CMRPG1B0571,CIRPG3B0032,CMRPG3F1601).

关键词 O-GLYCOSYLATION Post-translational modification GLYCOBIOLOGY Biomarkers Hepatocellular carcinoma(HCC) GLYCOSYLTRANSFERASE

分类号 R73 [医药卫生—肿瘤]

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参考文献1

1Terence CW Poon,Clarissa HS Chiu,Paul BS Lai,Tony SK Mok,Benny Zee,Anthony TC Chan,Joseph JY Sung,Philip J Johnson.Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma[J].World Journal of Gastroenterology,2005,11(42):6701-6706. 被引量：4

二级参考文献11

1Fabio Dall’Olio,Mariella Chiricolo.Sialyltransferases in cancer[J].Glycoconjugate Journal (-).2001(11-12)
2Cao Y,Merling A,Crocker PR,Keller R,Schwartz-Albiez R.Differential expression of beta-galactoside alpha2,6 sialyltransferase and sialoglycans in normal and cirrhotic liver and hepatocellular carcinoma[].Laboratory Investigation.2002
3Nomura F,Ohnishi K,Tanabe Y.Clinical features and prognosis of hepatocellular carcinoma with reference to serum alpha-fetoprotein levels.Analysis of 606 patients[].Cancer.1989
4Halliday JA,Franks AH,Ramsdale TE,Martin R,Palant E.A rapid, semi-automated method for detection of Galbetal-4GlcNAc alpha2,6-sialyltransferase (EC 2.4.99.1) activity using the lectin Sambucus nigra agglutinin[].Glycobiology.2001
5Collard JG,Schijven JF,Bikker A,La Riviere G,Bolscher JG,Roos E.Cell surface sialic acid and the invasive and metastatic potential of T-cell hybridomas[].Cancer Research.1986
6Lok AS,Lai CL.alpha-Fetoprotein monitoring in Chinese patients with chronic hepatitis B virus infection: role in the early detection of hepatocellular carcinoma[].Hepatology.1989
7Johnson PJ,Portmann B,Williams R.Alpha-fetoprotein concentrations measured by radioimmunoassay in diagnosing and excluding hepatocellular carcinoma[].British Medical Journal.1978
8Wang PH,Li YF,Juang CM,Lee YR,Chao HT,Tsai YC,Yuan CC.Altered mRNA expression of sialyltransferase in squamous cell carcinomas of the cervix[].Gynecologic Oncology.2001
9Johnson PJ,Poon TC,Hjelm NM,Ho CS,Blake C,Ho SK.Structures of disease-specific serum alpha-fetoprotein isoforms[].British Journal of Cancer.2000
10Pousset D,Filler V,Bureaud N,Monsigny M,Filler F.Increased alpha2,6 sialylation of N-glycans in a transgenic mouse model of hepatocellular carcinoma[].Cancer Research.1997

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1夏磊(综述),王元书(审校),崔淑香(审校).唾液酸转移酶与肿瘤进展和转移[J].国际肿瘤学杂志,2009,36(2):86-88. 被引量：4
2刘敏.中老年肝癌患者血清中MMP-2、MMP-9和AFP表达及其意义[J].中国老年学杂志,2012,32(1):171-172. 被引量：7
3魏巍,孙杰,郭瑞,杨梅,史姝,杨进.糖基因ST6GAL家族在肝癌转移中的作用[J].中国微生态学杂志,2015,27(3):276-279. 被引量：1

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2孟庆华,侯维.2015年版《慢性乙型肝炎防治指南》——慢性乙型肝炎抗病毒治疗指南解读[J].中国全科医学,2016,19(14):1613-1615. 被引量：73
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4段慧.联合检测血清甲胎蛋白、癌胚抗原和糖类抗原125、糖类抗原15-3、糖类抗原19-9水平对原发性肝癌的诊断价值[J].中国卫生检验杂志,2023,33(2):224-227. 被引量：4
5张郴华,邓英.血清寡糖链与甲胎蛋白联合检测在肝细胞癌诊断及其预后评估中的应用价值分析[J].大医生,2023,8(9):122-125.
6郭冬萌,吴玉卓.肝癌患者血清中lncRNA HOTAIR表达与临床病理特征的相关性及诊断价值[J].实用癌症杂志,2023,38(5):737-740. 被引量：1
7杨高中,许阳院,刘珍花,汤雄.寡糖链检测技术在早期肝癌筛查中的应用[J].当代医学,2023,29(6):50-54.
8尚晓东.探讨罗式全自动电化学发光分析仪检测血清AFP、CEA在诊断肝癌中的应用[J].中国医疗器械信息,2024,30(3):107-109.
9崔裕健,刘涵云,张凤娟,杨超,梁坤,刘培,刘君香,毕春花.寡糖链检测在乙肝相关早期肝细胞癌中的预警价值研究[J].临床医学进展,2023,13(11):17880-17886.
10于苏淮,李栋栋,康文,贾晓黎.血清寡糖链检测在乙肝相关性肝癌中的诊断价值[J].医学诊断,2023,13(3):372-380.

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2Franklin T Johnson,Yanmin Zhu.Transcriptome changes in apple peel tissues during CO_(2)injury symptom development under controlled atmosphere storage regimens[J].Horticulture Research,2015,2(1):13-25. 被引量：1
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