镍催化的吲哚2-位二氟烷基化反应的研究

Nickel-catalyzed C(2)—H Difluoroalkylation of Indoles with Fuoroalkyl Halides

报道了一种用简单有效的镍催化吲哚化合物和卤代氟试剂,实现吲哚2-位C—H的二氟烷基化和全氟烷基化的反应。在该催化体系中,不论是N-取代吲哚衍生物,还是N-非取代的吲哚衍生物,均可获得较高收率。初步的机理研究表明:反应归属自由基途径。

An efficient and mild Ni-catalyzed C—H difluoromethylation and perfluoroalkylation of indoles with commonly available fluoroalkyl halides has been developed.This novel transformation has demonstrated both free indole derivatives and N-substituted indole derivatives could be used to obtain the desired products in good yields.Preliminary study suggests that radical pathway was involved in the catalytic cycle.